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Titolo:
Serotonin modifies the neuronal inhibitory responses to gamma-aminobutyricacid in the red nucleus: A microiontophoretic study in the rat
Autore:
Licata, F; Volsi, GL; Di Mauro, M; Fretto, G; Ciranna, L; Santangelo, F;
Indirizzi:
Univ Catania, Dept Physiol Sci, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 t Physiol Sci, I-95125 Catania, Italy
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 167, anno: 2001,
pagine: 95 - 107
SICI:
0014-4886(200101)167:1<95:SMTNIR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBELLAR PURKINJE-CELLS; EXCITATORY AMINO-ACIDS; IN-VITRO; MUSCLE-ACTIVITY; ANTEROGRADE TRANSPORT; RUBROSPINAL NEURONS; MACACA-FASCICULARIS; VESTIBULAR NUCLEUS; BURST DISCHARGE; INFERIOR OLIVE;
Keywords:
5-HT; GABA; receptors; red nucleus; microiontophoresis; neurochemistry; motor control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
89
Recensione:
Indirizzi per estratti:
Indirizzo: Licata, F Univ Catania, Dept Physiol Sci, I-95125 Catania, Italy Univ Catania Catania Italy I-95125 Sci, I-95125 Catania, Italy
Citazione:
F. Licata et al., "Serotonin modifies the neuronal inhibitory responses to gamma-aminobutyricacid in the red nucleus: A microiontophoretic study in the rat", EXP NEUROL, 167(1), 2001, pp. 95-107

Abstract

The effects of 5-hydroxytryptamine (5-HT) on the inhibitory responses evoked by gamma -aminobutyric acid (GABA) in neurons of the red nucleus (RN) were studied using a microiontophoretic technique. Extracellular unitary recordings performed in anesthetized rats demonstrated that 5-HT ejection influenced GABA-evoked inhibition in 94% of RN neurons, enhancing them in 52% and depressing them in 46% of cases. Both effects were specific and dose-dependent, although enhancements or depressions of the GABA responses were respectively inversely and directly related to the doses of 5-HT applied. The type of modulation exerted by 5-HT on the GABA responses was independent of the action of the amine on background firing. In fact, 5-HT induced an enhancement of the GABA responses in neurons mostly located in the rostraI RN and a depression in those in the caudal RN. The application of 8-hydroxy-2(di-n-propylamino)tetralin, a specific 5-HT2A receptor agonist, enhanced GABAresponses, whereas alpha -methyI-5-hydroxytryptamine, a 5-HT,A receptor agonist, depressed them. Both the 5-HT2 antagonist methysergide and the 5-MT,selective antagonist ketanserin were able to block partially or totally the depressive action of 5-HT on GABA responses. In contrast, the same 5-HT antagonists mimicked the enhancing action of 5-HT on the GABA responses or were ineffective. Application of bicuculline, a GABA, receptor antagonist, enhanced the excitatory action of 5-HT on the background firing and slightlyreduced the inhibitory action. It is concluded that 5-HT is able to modulate GABA-evoked responses in RN neurons by acting on both 5-HT1A and 5-HT2A receptors. The functional significance of a serotonergic control on GABAergic inhibitory effects in RN is discussed. (C) 2001 Academic Press.

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Documento generato il 31/03/20 alle ore 09:58:57