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Titolo:
Housing conditions influence the survival and body composition of ageing rats
Autore:
Skalicky, M; Narath, E; Viidik, A;
Indirizzi:
Aarhus Univ, Inst Anat, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 v, Inst Anat, DK-8000 Aarhus, Denmark Univ Vet Med, Inst Physiol, A-1210 Vienna, Austria Univ Vet Med Vienna Austria A-1210 Inst Physiol, A-1210 Vienna, Austria
Titolo Testata:
EXPERIMENTAL GERONTOLOGY
fascicolo: 1, volume: 36, anno: 2001,
pagine: 159 - 170
SICI:
0531-5565(200101)36:1<159:HCITSA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIOELECTRICAL-IMPEDANCE ANALYSIS; WISTAR RATS; EXERCISE; WEIGHT; TUMORS; WATER;
Keywords:
ageing; body composition; bioimpedance; survival; rat; housing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Viidik, A Aarhus Univ, Inst Anat, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus Denmark DK-8000 at, DK-8000 Aarhus, Denmark
Citazione:
M. Skalicky et al., "Housing conditions influence the survival and body composition of ageing rats", EXP GERONT, 36(1), 2001, pp. 159-170

Abstract

Ad libitum fed male Sprague-Dawley rats were randomly assigned to be housed individually (n = 32) or four in each cage (n = 32) from five to 23 months of age. Body weight and body composition by bioimpedance analysis were monitored longitudinally. An equation for analysis of body composition was developed. Deaths and causes of death were recorded. Of the individually housed animals (H1) 16 percent died, while 44 percent of those housed four in acage (H4) died, the most common causes of death being circulatory failure,nephritis and tumours of the hypophysis. Body weight increased in both groups over time, significantly more for H4 from 6 months of age. Both fat free mass and total body fat increased in both groups over time. Fat in percent of body weight increased up to an age of 14 months. H4 animals had significantly more fat from ii to 20 months of age but lost weight, mostly fat when approaching 23 months of age. The occiput-sacrum length of the animals increased up to 11 months of age and stayed then constant. Animals in both groups grew also in the cross-sectional dimension. The H1 animals continued to grow all the time, while the growth ofthe H4 animals stopped at the age of 17 months, when the mortality startedto become pronounced. It is concluded that housing conditions can modulate the outcome of the ageing of sedentary and otherwise not treated rats in long-term experiments. Further, the feasibility of monitoring body composition longitudinally withbioimpedance analysis was demonstrated. (C) 2001 Elsevier Science Inc. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:23:11