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Titolo:
The interface between pharmacoepidemiology and pharmacogenetics
Autore:
Maitland-van der Zee, AH; de Boer, A; Leufkens, HGM;
Indirizzi:
Univ Utrecht, UIPS, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3508 TB Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TB 3508 TB Utrecht, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 410, anno: 2000,
pagine: 121 - 130
SICI:
0014-2999(200012)410:2-3<121:TIBPAP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-ENVIRONMENT INTERACTION; MOLECULAR EPIDEMIOLOGY; ESSENTIAL-HYPERTENSION; ALZHEIMERS-DISEASE; APOLIPOPROTEIN-E; POLYMORPHISMS; RECEPTOR; THERAPY; RISK; BETA(2)-ADRENOCEPTOR;
Keywords:
pharmacogenetics; polymorphism; pharmacotherapy; pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Leufkens, HGM Univ Utrecht, UIPS, Dept Pharmacoepidemiol & Pharmacotherapy, Sorbonnelaan16,POB 80082, NL-3508 TB Utrecht, Netherlands Univ Utrecht Sorbonnelaan 16,POB 80082 Utrecht Netherlands NL-3508 TB
Citazione:
A.H. Maitland-van der Zee et al., "The interface between pharmacoepidemiology and pharmacogenetics", EUR J PHARM, 410(2-3), 2000, pp. 121-130

Abstract

One of the most challenging areas of research in pharmacoepidemiology is to understand why individuals respond differently to drug therapy, both in terms of beneficial and adverse effects. Pharmacogenetics focuses on the question to what extent variability in genetic make-up is responsible for these observed differences. Pharmacoepidemiologic research can contribute to pharmacogenetics by explaining the observed variability in drug response in 'real life' patient populations with known polymorphisms in their genetic profile. Genetic pharmacoepidemiologists also are interested in the distribution of polymorphisms and correlated frequencies of responders and non-responders in the general population, and in searching for unknown genetic linksto variability in drug response. In the future, we will probably have fewer drugs that suit all individuals. Genetic pharmacoepidemiology is going toplay a major role in the development and evaluation of the concept of 'tailor-made' pharmacotherapy. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:28:04