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Titolo:
RR interval variation, the QT interval index and risk of primary cardiac arrest among patients without clinically recognized heart disease
Autore:
Whitsel, EA; Raghunathan, TE; Pearce, RM; Lin, D; Rautaharju, PM; Lemaitre, R; Siscovick, DS;
Indirizzi:
Cardiovasc Hlth Res Unit, Seattle, WA USA Cardiovasc Hlth Res Unit Seattle WA USA c Hlth Res Unit, Seattle, WA USA Vet Affairs Puget Sound Hlth Care Syst, Hlth Serv Res & Dev Field Program,Seattle, WA USA Vet Affairs Puget Sound Hlth Care Syst Seattle WA USA am,Seattle, WA USA Univ Washington, Dept Med, Seattle, WA USA Univ Washington Seattle WA USA niv Washington, Dept Med, Seattle, WA USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Biostat, Ann Arbor, MI 48109 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Epidemiol Cardiol Res Ctr, Winston Salem, NC 27103 USA Wake Forest Univ Winston Salem NC USA 27103 , Winston Salem, NC 27103 USA
Titolo Testata:
EUROPEAN HEART JOURNAL
fascicolo: 2, volume: 22, anno: 2001,
pagine: 165 - 173
SICI:
0195-668X(200101)22:2<165:RIVTQI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTONOMIC NERVOUS-SYSTEM; RATE-VARIABILITY; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; MORTALITY; ELECTROCARDIOGRAPHY; PROLONGATION; ABNORMALITIES; PROPRANOLOL; CRITERIA;
Keywords:
autonomic function; cardiac arrest; electrocardiography; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Whitsel, EA Univ N Carolina, Dept Epidemiol, Cardiovasc Dis Program, Bank Amer Ctr, Suite 306,137 E Franklin St, Chapel Hill, NC 27514 USA Univ N Carolina Suite 306,137 E Franklin St Chapel Hill NC USA 27514
Citazione:
E.A. Whitsel et al., "RR interval variation, the QT interval index and risk of primary cardiac arrest among patients without clinically recognized heart disease", EUR HEART J, 22(2), 2001, pp. 165-173

Abstract

Aims Autonomic tone influences RR interval variation (RRV) and the heart rate-corrected QT interval index (QTI). Together, QTI and RRV may improve characterization of sympathovagal control and estimation of risk of primary cardiac arrest. We therefore examined effects of QTI and short-term RRV fromstandard, 12-lead electrocardiograms on risk of primary cardiac arrest among persons without clinically recognized heart disease. Methods and Results We analysed data from a case-control study of risk factors for primary cardiac arrest among enrollees in a large health plan. Cases (n=505) were enrollees aged 18 to 79 years without history of heart disease who had primary cardiac arrest between 1980 and 1994. Controls (n=529) were a demographically similar, stratified random sample of enrollees. We determined enrollee characteristics from ambulatory medical records, QTI andRRV from standard, 12-lead electrocardiograms, and medication use from automated pharmacy files. Low and high Values of QTI and RRV were designated as the first and fifth quintiles of QTI (96% and 107%) and RRV (35 ms and 120 ms) among controls. In a model adjusting for clinical predictors of primary cardiac arrest, RRV modified the association between QTI and risk of primary cardiac arrest (P=0(.)05). Compared to high RRV and low QTI, the risk of primary cardiac arrest (odds ratio [95% CI]) was 0(.)95 [0(.)73-1(.)23] at low RRV and QTI, 1(.)23 [0(.)97-1(.)57] at high RRV and QTI, and 1(.)55 [1(.)16-2(.)06] at low RRV and high QTI. Risk remained elevated after adjustment for other electrocardiographic predictors and medication use. Conclusion Autonomic dysfunction, characterized by high QTI and low RRV onthe standard, 12-lead electrocardiogram, is associated with an increased risk of primary cardiac arrest among persons without clinically recognized heart disease. (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 06:09:50