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Titolo:
The autoregulation of retinal ganglion cell number
Autore:
Gonzalez-Hoyuela, M; Barbas, JA; Rodriguez-Tebar, A;
Indirizzi:
CSIC, Inst Cajal Neurobiol, E-28002 Madrid, Spain CSIC Madrid Spain E-28002 C, Inst Cajal Neurobiol, E-28002 Madrid, Spain
Titolo Testata:
DEVELOPMENT
fascicolo: 1, volume: 128, anno: 2001,
pagine: 117 - 124
SICI:
0950-1991(200101)128:1<117:TAORGC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; CHICK RETINA; NEUROTROPHIC FACTOR; TRANSCRIPTION FACTORS; TYROSINE-HYDROXYLASE; P75 RECEPTOR; CONE CELLS; RAT RETINA; DIFFERENTIATION; EXPRESSION;
Keywords:
chick embryo; retina development; neuron number; neurogenesis; apoptosis; retinal ganglion cells; NGF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez-Tebar, A CSIC, Inst Cajal Neurobiol, Ave Doctor Arce 37, E-28002Madrid, Spain CSIC Ave Doctor Arce 37 Madrid Spain E-28002 id, Spain
Citazione:
M. Gonzalez-Hoyuela et al., "The autoregulation of retinal ganglion cell number", DEVELOPMENT, 128(1), 2001, pp. 117-124

Abstract

The development of the nervous system is dependent on a complex set of signals whose precise co-ordination ensures that the correct number of neurones are generated, This regulation is achieved through a variety of cues thatinfluence both the generation and the maintenance of neurones during development. We show that in the chick embryo, stratified retinal ganglion cells(RGCs) are themselves responsible for providing the signals that control the number of RGCs that are generated, both by inhibiting the generation of new ganglion cells and by killing incoming migratory ganglion cells. Selective toxicological ablation of RGCs in the chick embryo resulted in the achronic generation of ganglion cells, which eventually led to the repopulationof the ganglion cell layer and a large decrease in the physiological cell death affecting postmitotic migratory neurones. Interestingly, the application of exogenous NGF reversed the effects of ganglion cell ablation on ganglion cell death. Because the only source of NGF in the retina is that produced by the stratified ganglion cells, we infer that these differentiated neurones regulate their own cell number by secreting NGF, a neurotrophin thathas previously been shown to be responsible for the death of migrating ganglion cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 04:55:16