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Titolo:
Dextran, gelatin, and hydroxyethyl starch do not affect permeability for albumin in cat skeletal muscle
Autore:
Holbeck, S; Bentzer, P; Wikstrand, C; Grande, PO;
Indirizzi:
Univ Lund Hosp, Dept Anaesthesia & Intens Care, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 a & Intens Care, S-22185 Lund, Sweden Univ Lund Hosp, Dept Physiol, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 p, Dept Physiol, S-22185 Lund, Sweden
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 1, volume: 29, anno: 2001,
pagine: 123 - 128
SICI:
0090-3493(200101)29:1<123:DGAHSD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPILLARY FLUID PERMEABILITY; MICROVASCULAR PERMEABILITY; PLASMA-VOLUME; INJURY; MACROMOLECULES; RESUSCITATION; COEFFICIENT; COLLOIDS; CHARGE; SHOCK;
Keywords:
albumin; blood flow; capillary permeability; capillary filtration coefficient; colloids; dextran; fluid therapy; gelatin; hydroxyethyl starch; reflection coefficient; skeletal muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Holbeck, S Univ Lund Hosp, Dept Anaesthesia & Intens Care, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 Care, S-22185 Lund, Sweden
Citazione:
S. Holbeck et al., "Dextran, gelatin, and hydroxyethyl starch do not affect permeability for albumin in cat skeletal muscle", CRIT CARE M, 29(1), 2001, pp. 123-128

Abstract

Objective: To evaluate the effects of the three commercially available colloid solutions, 6% dextran 70, 6% hydroxyethyl starch (HES) 200/0.5, and 3.5% urea-linked gelatin on permeability for human albumin in a skeletal muscle in vivo model by evaluating their effects on the reflection coefficient for albumin,Design: Controlled laboratory study. Setting: University research laboratory. Subjects: Eighteen adult cats. Interventions: The autoperfused and denervated calf muscles of the cat hindlimb were placed in a plethysmograph. The transvascular fluid absorption induced by an increase in the colloid osmotic pressure following a fixed intravenous bolus of human albumin was analyzed, first before start of, and then during an intra-arterial infusion to, the muscle preparation of the synthetic colloid to be analyzed. Capillary filtration coefficient as a measureof microvascular fluid permeability (conductance) was analyzed before and after start of the synthetic colloid. Measurements and Main Results:Arterial blood flow, arterial and venous blood pressures, total vascular resistance, tissue volume changes, capillary filtration coefficient, and plasma volume were measured before and during the colloid infusion. According to the Starling fluid equilibrium, the ratio between the reflection coefficients for albumin on two occasions (before and after infusion of the synthetic colloid) can be calculated from the maximum osmotic absorption rates induced by a fixed intravenous bolus infusion of albumin and from the capillary filtration coefficients. Obtained data were adjusted for different plasma volume at the two occasions. We found that none of the three synthetic colloids analyzed had any significant effect onthe reflection coefficient for albumin. Conclusion: An effect on albumin microvascular permeability of the synthetic colloids dextran 70, HES 200/0.5, and urea-linked gelatin could not be shown by a method analyzing their effect on the reflection coefficient for albumin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:37:03