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Titolo:
Tl201SPECT compared with histopathologic grade in the prognostic assessment of cerebral gliomas
Autore:
Higa, T; Maetani, S; Yoichiro, K; Nabeshima, S;
Indirizzi:
Tenri Hosp, Radioisotope Ctr, Tenri, Nara 6320015, Japan Tenri Hosp TenriNara Japan 6320015 otope Ctr, Tenri, Nara 6320015, Japan Tenri Inst Med Res, Tenri, Nara, Japan Tenri Inst Med Res Tenri Nara Japan nri Inst Med Res, Tenri, Nara, Japan Tenri Hosp, Dept Neurosurg, Tenri, Nara 632, Japan Tenri Hosp Tenri Nara Japan 632 p, Dept Neurosurg, Tenri, Nara 632, Japan
Titolo Testata:
CLINICAL NUCLEAR MEDICINE
fascicolo: 2, volume: 26, anno: 2001,
pagine: 119 - 124
SICI:
0363-9762(200102)26:2<119:TCWHGI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; TL-201 SPECT; COMPUTERIZED-TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; GLIOBLASTOMA-MULTIFORME; BRAIN-TUMOR; SURVIVAL; ASTROCYTOMA; RECURRENCE; DIAGNOSIS;
Keywords:
brain neoplasms; diagnosis; emission computed tomography; radionuclide studies; statistical analysis; Tl-201;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Higa, T Tenri Hosp, Radioisotope Ctr, 200 Mishima Cho, Tenri, Nara 6320015, Japan Tenri Hosp 200 Mishima Cho Tenri Nara Japan 6320015 6320015, Japan
Citazione:
T. Higa et al., "Tl201SPECT compared with histopathologic grade in the prognostic assessment of cerebral gliomas", CLIN NUCL M, 26(2), 2001, pp. 119-124

Abstract

Purpose: Although TI-201 SPECT has been used to evaluate the malignant grade of cerebral gliomas, the gold standard continues to be histopathologic examination. The authors assessed and compared the prognostic abilities of the two studies using survival analysis. Materials and Methods: Twenty-nine patients underwent 34 sessions of TI-201 SPECT plus surgery for primary or recurrent cerebral gliomas 12 to 78 months before this analysis. Using conventional survival analyses, such as thelog-rank test, Cox regression, and the Akaike cross-tab method, the authors evaluated the prognostic significance of 10 variables: histopathologic grade, TI-201 SPECT, Tc-99m HMPAO SPECT, tumor cell viability, radionecrosis,neurologic defects, clinical improvement, surgery, chemotherapy, and external beam radiotherapy. Results: TI-201 SPECT was most strongly related to prognosis, followed by histopathologic grade. The other variables had little prognostic value. TheCox stepwise selection procedure indicated that TI-201 SPECT was the only independent predictor of outcome, whereas histopathologic analysis was eliminated from the prognostic model. However, the Kaplan-Meier survival curve and the Akaike method indicated that histopathologically tow-grade tumors were more closely associated with longer-term survival than were TI-201 low uptake tumors. Conclusions: TI-201 SPECT is not only closely correlated with the histopathologic grade of tumor but is a significantly better predictor of outcome than histopathologic grade. However, histopathologic examination may provideadditional information on longer-term survival. TI-201 SPECT is a valuableprocedure, especially in patients in whom a histologic diagnosis of possible glioma cannot be made.

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Documento generato il 26/09/20 alle ore 05:20:19