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Titolo:
Reconstitution of self-reactive antibody repertoires of autologous plasma IgM in patients with non-Hodgkin's lymphoma following myeloablative therapy
Autore:
Stahl, D; Yeshurun, M; Gorin, NC; Sibrowski, W; Kaveri, SV; Kazatchkine, MD;
Indirizzi:
Univ Munster, Inst Transfus Med, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 nsfus Med, D-48149 Munster, Germany INSERM, U430, F-75014 Paris, France INSERM Paris France F-75014INSERM, U430, F-75014 Paris, France Univ Paris 06, Hop Broussais, F-75014 Paris, France Univ Paris 06 Paris France F-75014 Hop Broussais, F-75014 Paris, France Hop St Antoine, Dept Hematol, F-75012 Paris, France Hop St Antoine ParisFrance F-75012 Dept Hematol, F-75012 Paris, France
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 98, anno: 2001,
pagine: 31 - 38
SICI:
1521-6616(200101)98:1<31:ROSARO>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; STEM-CELL TRANSPLANTATION; NATURAL AUTOANTIBODIES; HEALTHY-ADULTS; SERUM IGM; ANTIGENS; STABILITY; SET;
Keywords:
self-reactivity; antibody repertoires; IgM; autologous blood stem cell transplantation; non-Hodgkin's lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Stahl, D Univ Munster, Inst Transfus Med, Domagkstr 11, D-48149 Munster, Germany Univ Munster Domagkstr 11 Munster Germany D-48149 nster, Germany
Citazione:
D. Stahl et al., "Reconstitution of self-reactive antibody repertoires of autologous plasma IgM in patients with non-Hodgkin's lymphoma following myeloablative therapy", CLIN IMMUNO, 98(1), 2001, pp. 31-38

Abstract

In healthy individuals, natural self-reactive antibody repertoires are restricted to a limited subset of autoantigens that is selected early in development and that remains invariant between individuals through aging. In thepresent study, we addressed the question of whether self-reactive antibodyrepertoires of plasma IgM change during high-dose chemotherapy (HDCT) withautologous blood stem cell support and whether antibody repertoires generated during immune reconstitution are similar to those present under physiological conditions. We followed the development of antibody repertoires in patients undergoing HDCT for the treatment of B-cell non-Hodgkin's lymphoma (NHL). Antibody repertoires were investigated by quantitative immunoblotting on whole tissue extracts as sources of self-antigens and by multiparametric statistical analysis of the data. We demonstrate that self-reactive antibody repertoires of plasma IgM of NHL patients prior to HDCT differ from those of healthy individuals, that they change during recovery of immune functions, and that antibody repertoires similar to those of healthy individuals are generated during immune reconstitution. We conclude that the mechanisms responsible for the selection of self-reactive repertoires of autologousplasma IgM during immune reconstitution after HDCT may follow those present under physiological conditions and that immune reconstitution may includea shift from altered toward normal patterns of self-reactivity. (C) 2000 Academic Press.

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Documento generato il 28/09/20 alle ore 15:31:55