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Titolo:
Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively
Autore:
Constantinescu, CS; Hilliard, B; Ventura, E; Wysocka, M; Showe, L; Lavi, E; Fujioka, T; Scott, P; Trinchieri, G; Rostami, A;
Indirizzi:
Univ Nottingham, Queens Med Ctr, Sch Med, Div Clin Neurol, Nottingham NG7 2UH, England Univ Nottingham Nottingham England NG7 2UH , Nottingham NG7 2UH, England Univ Penn, Med Ctr, Dept Neurol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 pt Neurol, Philadelphia, PA 19104 USA Univ Leicester, Dept Microbiol & Immunol, Leicester LE1 9HN, Leics, England Univ Leicester Leicester Leics England LE1 9HN er LE1 9HN, Leics, England Univ Penn, Sch Med, Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 at & Biol, Philadelphia, PA 19104 USA Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pathobiol, Philadelphia, PA 19104 USA Univ Penn, Med Ctr, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 98, anno: 2001,
pagine: 23 - 30
SICI:
1521-6616(200101)98:1<23:MOSART>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; CENTRAL-NERVOUS-SYSTEM; T-CELL CLONES; NECROSIS-FACTOR-ALPHA; LEISHMANIA-MAJOR; CUTANEOUS LEISHMANIASIS; GAMMA PRODUCTION; TRANSGENIC MICE; C57BL/6 MICE;
Keywords:
multiple sclerosis; experimental autoimmune; encephalomyelitis; Th1/Th2; IL-12; IL-4;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Constantinescu, CS Univ Nottingham, Queens Med Ctr, Sch Med, Div Clin Neurol, Floor B, Nottingham NG7 2UH, England Univ Nottingham Floor B Nottingham England NG7 2UH and
Citazione:
C.S. Constantinescu et al., "Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively", CLIN IMMUNO, 98(1), 2001, pp. 23-30

Abstract

Experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis, is mediated by Th1 cells. The major Th1 inducer, IL-12, enhances EAE, while its blockade suppresses it. IL-4 suppresses EAE. Here, we determined IFN-gamma and IL-4 production by myelin basic protein-stimulated lymphocytes from prototypically EAE-susceptible SJL/J and EAE-resistant BALB/c mice, 9 days after immunization with spinal cord homogenate, While lymphocytes from SJL/J mice produce IFN-gamma and no IL-4, lymphocytes from BALB/c mice produce IL-4 and no IFN-gamma. Since early endogenous production of IL-12/IFN-gamma or IL-4 is linked to Th1 or Th2 responses, respectively, we determined whether neutralization of IL-12 or IL-4 at immunization modifies susceptibility or resistance to EAE, SJL/J mice given neutralizing anti-IL-12 mAb are protected from EAE. BALB/c mice given neutralizing anti-IL-1mAb develop EAE, while those treated with control antibody remain resistant. These studies confirm the pivotal role of IL-12 in EAE development and show that endogenous IL-4 is important for determining the genetic resistance to EAE. (C) 2000 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:25:06