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Titolo:
Nucleic acid conformation diversity: from structure to function and regulation
Autore:
Belmont, P; Constant, JF; Demeunynck, M;
Indirizzi:
Univ Grenoble 1, Etud Dynam & Struct Select Lab, Chim Bioorgan Lab, CNRS,UMR 5616, F-38041 Grenoble 9, France Univ Grenoble 1 Grenoble France 9 S,UMR 5616, F-38041 Grenoble 9, France
Titolo Testata:
CHEMICAL SOCIETY REVIEWS
fascicolo: 1, volume: 30, anno: 2001,
pagine: 70 - 81
SICI:
0306-0012(200101)30:1<70:NACDFS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HANDED Z-DNA; HOLLIDAY JUNCTION; SMALL-MOLECULE; TELOMERASE INHIBITORS; CRUCIFORM STRUCTURES; HAMMERHEAD RIBOZYME; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; QUADRUPLEX DNA; CATALYTIC RNA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Belmont, P Univ Grenoble 1, Etud Dynam & Struct Select Lab, Chim Bioorgan Lab, CNRS,UMR 5616, BP 53, F-38041 Grenoble 9, France Univ Grenoble 1 BP 53Grenoble France 9 041 Grenoble 9, France
Citazione:
P. Belmont et al., "Nucleic acid conformation diversity: from structure to function and regulation", CHEM SOC RE, 30(1), 2001, pp. 70-81

Abstract

Nucleic acids are the structural supports of genetic material and therefore the key factors in many vital cellular processes. The double-stranded right-handed helix is a regular conformation adopted by both DNA and RNA in cells, but an increasing number of results point to the biological importanceof alternative structures such as bulges, hairpins, branched junctions or quadruplexes. Progress in the chemical synthesis of oligonucleotides and inthe knowledge of the factors that favour a particular conformation has opened new fields of research in molecular recognition and drug design.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:42:09