Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Molecular mechanisms of death-receptor-mediated apoptosis
Autore:
Sartorius, U; Schmitz, I; Krammer, PH;
Indirizzi:
German Canc Res Ctr, Div Immunogenet, Tumor Immunol Program, D-69120 Heidelberg, Germany German Canc Res Ctr Heidelberg Germany D-69120 69120 Heidelberg, Germany
Titolo Testata:
CHEMBIOCHEM
fascicolo: 1, volume: 2, anno: 2001,
pagine: 20 - 29
SICI:
1439-4227(20010108)2:1<20:MMODA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PROGRAMMED CELL-DEATH; INTERLEUKIN-1-BETA CONVERTING-ENZYME; FLICE-INHIBITORY PROTEIN; DOMAIN-CONTAINING PROTEIN; TRAIL-INDUCED APOPTOSIS; SIGNALING COMPLEX DISC; BCL-2 FAMILY PROTEINS; CYTOCHROME-C RELEASE; CD95 TYPE-I;
Keywords:
apoptosis; biological signal transduction; CD95; receptors; tumor therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
158
Recensione:
Indirizzi per estratti:
Indirizzo: Krammer, PH German Canc Res Ctr, Div Immunogenet, Tumor Immunol Program, Neuenheimer Feld 280, D-69120 Heidelberg, Germany German Canc Res Ctr Neuenheimer Feld 280 Heidelberg Germany D-69120
Citazione:
U. Sartorius et al., "Molecular mechanisms of death-receptor-mediated apoptosis", CHEMBIOCHEM, 2(1), 2001, pp. 20-29

Abstract

Apoptosis, also called "programmed cell death", can be induced by a variety of stimuli including activation of death receptors by the corresponding death ligands. Death receptors are a subgroup of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily and are characterized by a death domain, which is required for signal transduction. Upon apoptosisinduction, caspases, a family of aspartyl-specific cysteine proteases, areactivated, which are the main executioners of apoptosis. Finally, specificdeath substrates are cleaved, resulting in the morphologic features of apoptosis. Depending on the cell type, activation of mitochondria is of central significance for apoptosis induction. This signaling pathway can be modulated by different pro- and anti-apoptotic proteins such as Bax and Bcl-2, which are localized at the mitochondria. Furthermore, apoptosis initiation can be prevented at the death receptor level by FLICE (caspase-8)-inhibitoryproteins (FLIPs). Deregulation of apoptosis is associated with diseases like cancer, autoimmunity, and AIDS. Therefore, the elucidation of cell deathpathways and the identification of modulators of apoptosis have many therapeutic implications.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 21:46:00