Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
K-CI cotransport: Properties and molecular mechanism
Autore:
Lauf, PK; Adragna, NC;
Indirizzi:
Wright State Univ, Dept Physiol & Biophys, Dayton, OH 45435 USA Wright State Univ Dayton OH USA 45435 iol & Biophys, Dayton, OH 45435 USA Wright State Univ, Dept Pharmacol & Toxicol, Dayton, OH USA Wright State Univ Dayton OH USA Dept Pharmacol & Toxicol, Dayton, OH USA
Titolo Testata:
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
fascicolo: 5-6, volume: 10, anno: 2000,
pagine: 341 - 354
SICI:
1015-8987(2000)10:5-6<341:KCPAMM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RED-BLOOD-CELLS; ASCITES TUMOR-CELLS; PASSIVE POTASSIUM-TRANSPORT; LK SHEEP ERYTHROCYTES; CL COTRANSPORT; ION-TRANSPORT; NA/H EXCHANGE; COORDINATED REGULATION; FUROSEMIDE INHIBITION; CHLORIDE TRANSPORT;
Keywords:
K-CI cotransport; KCC proteins; thermodynamics; activators; inhibitors; cell volume regulation; erythrocytes; nucleated cells; properties;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Lauf, PK Wright State Univ, Dept Physiol & Biophys, 3640 Colonel Glenn Highway, Dayton, OH 45435 USA Wright State Univ 3640 Colonel Glenn Highway Dayton OH USA 45435
Citazione:
P.K. Lauf e N.C. Adragna, "K-CI cotransport: Properties and molecular mechanism", CELL PHYS B, 10(5-6), 2000, pp. 341-354

Abstract

K-Cl cotransport (COT), defined first in red blood cells as the Cl-dependent, ouabain-insensitive bidirectional K transport, encoded by at least fourKCC (kalium-chloride-cotransport) genes, is now recognized as a functionaland structural reality in all cell membranes. As functional system, K-CI COT is necessary for volume and ionic homeostasis. Since its original discovery by swelling red cells in hyposmotic solutions and by treatment with N-ethylmaleimide (NEM), K-CI COT has been recognized as one of the prime electroneutral, low ion affinity pathways effecting regulatory volume decrease (RVD). This review first summarizes the general properties of K-CI GOT, including ion dependence, kinetics, thermodynamics and regulation in erythrocytes of various species, and then focuses on the newest findings of the molecular mechanisms behind K-CI GOT, the KCC isoforms and their expression in epithelial cells and in Xenopus oocytes. Based on early biophysical studies on red cells amalgamated with the recent molecular expression studies of the four KCC isoforms, K-CI COT emerges as one of the oldest membrane transporters that is controlled by a complex redox-dependent cascade of kinases and phosphatases, yet to be defined at the molecular level. Whereas RVD is a primeval role of KCI COT for survival of cells challenged by hyposmotic environments, maintenance of intracellular CI ([CI](i)) levels away from electrochemical equilibrium and K buffering capability during neuronal function are new additions to the list of physiological functions of this system. Copyright (C) 2000 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:26:39