Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms
Autore:
Coimbra, NC; Castro-Souza, C; Segato, EN; Nora, JEP; Herrero, CFPS; Tedeschi, W; Garcia-Cairasco, N;
Indirizzi:
Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCo Preto, SP, Brazil USP, FMRP, Dept Fisiol, Lab Neurofisiol & Neuroetol Expt, BR-14049900 Ribeirao Preto, SP, Brazil USP Ribeirao Preto SP Brazil BR-14049900 BC900 Ribeirao Preto, SP, Brazil
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 888, anno: 2001,
pagine: 314 - 320
SICI:
0006-8993(20010112)888:2<314:PAIOOS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR COLLICULUS; SUPERIOR COLLICULUS; WISTAR RATS; ANTINOCICEPTION; STIMULATION; CONVULSIONS; RECEPTORS; MORPHINE; EPILEPSY; TECTUM;
Keywords:
post-ictal analgesia; pentylenetetrazol; GABA(A) receptor; 5-HT2 receptor; endogenous opioid; muscarinic receptor; tail-flick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Coimbra, NC Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Farmacol, Lab Neuroanat & Neuropsicobiol, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BC Brazil
Citazione:
N.C. Coimbra et al., "Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms", BRAIN RES, 888(2), 2001, pp. 314-320

Abstract

The neural mechanisms involved in post-ictal analgesia remain to be elucidated. Pentylenetetrazol (PTZ) is used experimentally to induce seizure in animal subjects. This non-competitive antagonist blocks GABA-mediated Cl- flux. The aim of this work is to study the neurochemical basis of the antinociception induced by convulsions elicited by peripheral administration of PTZ (64 mg/kg). The analgesia was measured by the tail-flick test, in eight rats per group. Convulsions were followed by significant increase in the tail-flick latencies (TFL), at least for 30 min of the post-ictal period. Peripheral administration of naloxone (5 mg/kg and 10 mg/kg), atropine (1 mg/kgand 5 mg/kg), methysergide (1 mg/kg and 5 mg/kg) and ketanserine(1 mg/kg and 2 mg/kg) caused a significant decrease in the TFL in seizing animals, ascompared to controls. However, while naloxone antagonized analgesia 15 and25 min post convulsions, the other drugs caused a blockade of the post-ictal analgesia in a relatively greater period of time. These results indicatethat endogenous opioids, serotonin and acetylcholine may be involved in post-ictal analgesia. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:20:56