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Titolo:
Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action
Autore:
File, SE; Cheeta, S; Akanezi, C;
Indirizzi:
Univ London Kings Coll, GKT Sch Biomed Sci, Ctr Neurosci, Psychopharmacol Res Unit, London SE1 1UL, England Univ London Kings Coll London England SE1 1UL t, London SE1 1UL, England
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 888, anno: 2001,
pagine: 311 - 313
SICI:
0006-8993(20010112)888:2<311:DANISI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANXIETY; MOUSE; MICE; BENZODIAZEPINES; ANTAGONISTS; DEPRESSANT; TOLERANCE; BEHAVIOR; MARMOSET; EFFICACY;
Keywords:
anxiety; benzodiazepines; nicotine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: File, SE Univ London Kings Coll, GKT Sch Biomed Sci, Ctr Neurosci, Psychopharmacol Res Unit, Guys Campus, London SE1 1UL, England Univ London Kings Coll Guys Campus London England SE1 1UL ngland
Citazione:
S.E. File et al., "Diazepam and nicotine increase social interaction in gerbils: a test for anxiolytic action", BRAIN RES, 888(2), 2001, pp. 311-313

Abstract

The effects of two drugs with anxiolytic actions, diazepam (0.1, 0.3 and 1mg/kg) and nicotine (0.1 and 0.5 mg/kg) were examined on the time spent insocial interaction by pairs of male gerbils. In a test arena lit by high tight, diazepam (0.1 mg/k.g) increased social interaction, without changing locomotor activity. Diazepam (0.3 and 1 mg/kg) produced a dose-related increase in locomotor activity, which reached significance at the higher dose. Nicotine produced a dose-related increase in social interaction, which reached significance at 0.5 mg/kg, but was without effect on locomotor activity. The specific increases in social interaction observed with diazepam and nicotine are similar to those seen in the well-validated social interaction test of anxiety in rats and suggest that social interaction in gerbils may also be used to screen for anxiolytic action of novel compounds. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 23:53:52