Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Changes in sensitivity of cholinoceptors and adrenoceptors during transhemispheric cortical reorganisation in rat SmI
Autore:
Zarei, M; Raevsky, VV; Dawe, GS; Stephenson, JD;
Indirizzi:
Inst Psychiat, Dept Neurosci, London SE5 8AF, England Inst Psychiat London England SE5 8AF t Neurosci, London SE5 8AF, England Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England Russian Acad Sci, Inst Higher Nervous Act & Neurophysiol, Moscow, Russia Russian Acad Sci Moscow Russia rvous Act & Neurophysiol, Moscow, Russia
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 888, anno: 2001,
pagine: 267 - 274
SICI:
0006-8993(20010112)888:2<267:CISOCA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SOMATOSENSORY CORTEX; CHOLINERGIC RECEPTOR-BINDING; SCIATIC-NERVE; PLASTICITY; NEURONS; INJURY; ACETYLCHOLINE; LESIONS; ACETYLTRANSFERASE; NORADRENALINE;
Keywords:
reorganization; plasticity; acetylcholine; noradrenaline; brain damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Zarei, M Rivermead Rehabil Ctr, Abingdon Rd, Oxford OX1 0LR, England Rivermead Rehabil Ctr Abingdon Rd Oxford England OX1 0LR England
Citazione:
M. Zarei et al., "Changes in sensitivity of cholinoceptors and adrenoceptors during transhemispheric cortical reorganisation in rat SmI", BRAIN RES, 888(2), 2001, pp. 267-274

Abstract

The reorganisation of primary somatosensory cortex that occurs after lesioning the corresponding cortex of the contralateral hemisphere in rat has been termed, 'transhemispheric cortical reorganisation'. Cholinergic and noradrenergic innervations are hypothesized to be involved in cortical plasticity. The present study investigated the change in responses of somatosensoryneurones in the hindpaw representation area to muscarinic cholinoceptor and beta -adrenoceptor receptor stimulation, by iontophoretic application of acetylchorine, noradrenaline, propranolol and atropine, during the process of transhemispheric cortical reorganization at 3-4 days and at 20-21 days after lesioning the corresponding area in the contralateral hemisphere. Mostneurones in control rats showed excitatory atropine-sensitive responses toacetylcholine, and inhibitory propranolol-sensitive responses to noradrenaline. A marked reduction in neurones exhibiting muscarinic responses (from 69% to 22%) and beta -noradrenoceptor-mediated responses (from 62% to 24%) were seen in rats 3-4 days post lesion. The proportion of neurones responding had recovered by 3 weeks but the direction of the responses had changed with muscarinic response becoming predominantly inhibitory and beta -noradrenoceptor responses predominantly excitatory. It is concluded that transhemispheric cortical reorganization involves both receptor types and that the reciprocal changes at different stages after injury maintain cortical plasticity. (C) 2001 Elsevier Science B.V; All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:06:45