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Titolo:
Organization of vasoactive intestinal peptide-like immunoreactive system in the brain, olfactory organ and retina of the zebrafish, Danio rerio, during development
Autore:
Mathieu, M; Tagliafierro, G; Angelini, G; Vallarino, M;
Indirizzi:
Univ Genoa, Dipartimento Biol Sperimentale, DIBISAA, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 erimentale, DIBISAA, I-16132 Genoa, Italy
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 888, anno: 2001,
pagine: 235 - 247
SICI:
0006-8993(20010112)888:2<235:OOVIPI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTIDINE ISOLEUCINE-AMIDE; CHICK GALLUS-DOMESTICUS; CENTRAL-NERVOUS-SYSTEM; RAT-BRAIN; PROLACTIN-RELEASE; POLYPEPTIDE VIP; GENE-EXPRESSION; PITUITARY-GLAND; MESSENGER-RNA; VISUAL-CORTEX;
Keywords:
vasoactive intestinal peptide; development; brain; immunohistochemistry; zebrafish; Danio rerio;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Mathieu, M Univ Genoa, Dipartimento Biol Sperimentale, DIBISAA, Viale Benedetto XV, 5, I-16132 Genoa, Italy Univ Genoa Viale Benedetto XV, 5 Genoa Italy I-16132 oa, Italy
Citazione:
M. Mathieu et al., "Organization of vasoactive intestinal peptide-like immunoreactive system in the brain, olfactory organ and retina of the zebrafish, Danio rerio, during development", BRAIN RES, 888(2), 2001, pp. 235-247

Abstract

The localization of vasoactive intestinal peptide (VIP)-like immunoreactivity was investigated in the brain, olfactory system and retina of the zebrafish, Danio rerio, during development and in juvenile specimens, by using the indirect immunofluorescence and the peroxidase-antiperoxidase methods. In 24 h post fertilization (hpf) embryos,VIP-like immunoreactive cells were present in the olfactory pit, the retina, and several regions of the brain,including the dorsal telencephalon, the diencephalon, the tegmentum of themesencephalon, the caudal rhombencephalon and the anterior pituitary. In 48 hpf embryos, additional VIP-like immunoreactive cell bodies were found inthe ventral telencephalon, whereas in the diencephalon VIP-like immunopositive cells were more concentrated within the ventro-caudal hypothalamus. During the 7 day larval period, a dense plexus of VIP-like immunoreactive fibers first appeared in the olfactory bulbs. In 15-day-old larvae, two new groups of positive cells were observed in the periventricular preoptic nucleus and in the dorsal rhombencephalon. In 1 month/2 months old animals,VIP-like immunoreactive elements were confined to the olfactory organ, the olfactory bulbs, the periventricular preoptic nucleus and the pituitary, pars distalis. At 3 months stage, a large number of cells was observed in the periventricular preoptic nucleus. Western immunoblot analysis confirmed that VIP-like peptides, with molecular weight similar to that of synthetic VIP. arepresent early during the development of zebrafish. These results show thatVIP-like immunoreactive structures appear early during ontogeny both in the olfactory pit, retina and brain. Transient expression of positive cells was found in the retina, telencephalon, diencephalon and brainstem. The location of VIP-like immunoreactivity indicates that, during development, VIP could be involved in several neuromodulatory functions, including the processing of visual and olfactory informations, as well as growth or survival promotion activities. The presence of VIP-like immunopositive cells in the pituitary, pars distalis, suggest that, during development, VIP may influencethe secretion of pituitary hormones. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:31:22