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Titolo:
Estrogen modulates sexually dimorphic contextual fear conditioning and hippocampal long-term potentiation (LTP) in rats
Autore:
Gupta, RR; Sen, S; Diepenhorst, LL; Rudick, CN; Maren, S;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 sci Program, Ann Arbor, MI 48109 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 888, anno: 2001,
pagine: 356 - 365
SICI:
0006-8993(20010112)888:2<356:EMSDCF>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC SPINE DENSITY; SEX-DIFFERENCES; SYNAPTIC PLASTICITY; MICROTUS-PENNSYLVANICUS; NEURONAL TRANSMISSION; ANESTHETIZED RATS; FIELD POTENTIALS; CIRCADIAN-RHYTHM; OVARIAN HORMONES; SPATIAL MEMORY;
Keywords:
estrogen; fear conditioning; hippocampus; long-term potentiation; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Maren, S Univ Michigan, Dept Psychol, 525 E Univ Ave, Ann Arbor, MI 48109 USA Univ Michigan 525 E Univ Ave Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
R.R. Gupta et al., "Estrogen modulates sexually dimorphic contextual fear conditioning and hippocampal long-term potentiation (LTP) in rats", BRAIN RES, 888(2), 2001, pp. 356-365

Abstract

The present study examined the role of ovarian steroids in contextual fearconditioning and hippocampal synaptic plasticity in female rats. In experiment 1, adult female rats were ovariectomized and submitted to contextual fear conditioning, a procedure in which rats received unsignaled footshock in a novel observation chamber; freezing behavior served as the measure of conditional fear. Ovariectomized female rats froze at levels comparable to male rats, both of which froze significantly more than sham-operated female rats. In experiment (C), estrogen replacement in ovariectomized female ratsreduced fear conditioning to a level comparable to that of sham-operated females in experiment 1. In experiment 3, the influence of estrogen on the induction of long-term potentiation (LTP) at perforant path-dentate granule cell synapses in ovariectomized female rats was examined. Estrogen decreased both population spike LTP and EPSP-spike potentiation at perforant path synapses. Taken together, these experiments indicate that ovarian steroids regulate both sexually dimorphic behavior and hippocampal plasticity in a fear-conditioning paradigm. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 04/04/20 alle ore 02:36:00