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Titolo:
Prohibitin expression is increased in phorbol ester-treated chronic leukemic B-lymphocytes
Autore:
Woodlock, TJ; Bethlendy, G; Segel, GB;
Indirizzi:
Univ Rochester, Med Ctr, Sch Med & Dent, Dept Med, Rochester, NY 14642 USAUniv Rochester Rochester NY USA 14642 , Dept Med, Rochester, NY 14642 USA Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 ept Pediat, Rochester, NY 14642 USA Unity Hlth Syst, Rochester, NY 14642 USA Unity Hlth Syst Rochester NY USA14642 Hlth Syst, Rochester, NY 14642 USA
Titolo Testata:
BLOOD CELLS MOLECULES AND DISEASES
fascicolo: 1, volume: 27, anno: 2001,
pagine: 27 - 34
SICI:
1079-9796(200102)27:1<27:PEIIIP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID TRANSPORTER; ANTISENSE OLIGONUCLEOTIDES; CELL SORTER; DIFFERENTIATION; PROTEINS; SECRETION; INDUCTION; ANTIBODY; RECEPTOR; LINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Segel, GB Univ Rochester, Med Ctr, Sch Med & Dent, Dept Med, 601 Elmwood Ave,Box 777, Rochester, NY 14642 USA Univ Rochester 601 Elmwood Ave,Box 777 Rochester NY USA 14642 SA
Citazione:
T.J. Woodlock et al., "Prohibitin expression is increased in phorbol ester-treated chronic leukemic B-lymphocytes", BL CELL M D, 27(1), 2001, pp. 27-34

Abstract

Chronic lymphocytic leukemia (CLL) is characterized by the gradual accumulation of immature B-lymphocytes CLL B-lymphocytes mature to a plasmacytoid phenotype when treated in vitro with phorbol esters. CLL B-cell apparent maturation is associated with altered expression of specific plasma membrane and mitochondrial proteins including heightened expression of a 30-kDa heatshock protein 60 (hsp60) analog. During our efforts to further characterize this hsp60 analog by mass spectrometry, Eve detected the mitochondrial protein prohibitin in phorbol-ester-matured CLL B-lymphocytes Prohibitin modulates cell proliferation and inhibits cell cycle traverse in several systems, although few data are available far lymphocytes A twofold increase in prohibitin concentration was observed in phorbol-ester-mature d compared to resting CLL B-cells as determined by quantitative Western immunoblot analysis. A similar increase in prohibitin was observed in phorbol-ester-treated normal human B-lymphocyte populations. An antisense oligonucleotide complementary to the 5' coding region of the prohibitin gene blunted the increase in prohibitin protein in phorbol-ester-treated CLL, B-cells by 42%. These data suggest that increased prohibitin expression is associated with and may facilitate B-cell maturation. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:35:00