Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Totally synthetic polymer with lectin-like function: Induction of killer cells by the copolymer of 3-acrylamidophenylboronic acid with N,N-Dimethylacrylamide
Autore:
Uchimura, E; Otsuka, H; Okano, T; Sakurai, Y; Kataoka, K;
Indirizzi:
Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Univ Tokyo Tokyo Japan 1138656 Mat Sci, Bunkyo Ku, Tokyo 1138656, Japan Tokyo Womens Med Univ, Inst Biomed Engn, Shinjuku Ku, Tokyo 1628666, JapanTokyo Womens Med Univ Tokyo Japan 1628666 njuku Ku, Tokyo 1628666, Japan
Titolo Testata:
BIOTECHNOLOGY AND BIOENGINEERING
fascicolo: 3, volume: 72, anno: 2001,
pagine: 307 - 314
SICI:
0006-3592(20010205)72:3<307:TSPWLF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-2 RECEPTOR; CONCANAVALIN-A; T-LYMPHOCYTES; IN-VITRO; PHYTOHEMAGGLUTININ; COMPLEXES; CARRIERS; LYSIS; FORM;
Keywords:
artificial lectin; boronate-containing polymer; lymphocytes; proliferation; immuno-adjuvants; N-acetylneuraminic acid (sialic acid);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kataoka, K Univ Tokyo, Grad Sch Engn, Dept Mat Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan Univ Tokyo 7-3-1 Hongo Tokyo Japan 1138656 okyo 1138656, Japan
Citazione:
E. Uchimura et al., "Totally synthetic polymer with lectin-like function: Induction of killer cells by the copolymer of 3-acrylamidophenylboronic acid with N,N-Dimethylacrylamide", BIOTECH BIO, 72(3), 2001, pp. 307-314

Abstract

Lectin-like function was demonstrated in this study for a novel water-soluble polymer with phenylboronic acid residues (poly (AAPBA-DMAm)), which induced appreciable proliferation of murine spleen lymphocytes with an increased expression of interleukin-2 (IL-2) receptor on their surface. Consequently, boosted proliferation of lymphocytes with cytotoxic action to YAC-1 cells was achieved by concurrent addition of IL-2 with poly(AAPBA-DMAm) in themedium, indicating this boronate-containing polymer to be worked as an effective immuno-adjuvant for the induction of lymphokine-activated killer (LAK) cells. Flow-cytofluorimetry study revealed that poly(AAPBA-DMAm) competitively inhibited the cellular binding of N-acetylneuraminic acid-specific lectin (Limax Flavus Agglutinin) in a concentration-dependent manner, suggesting that phenylboronate moiety in the polymer may recognize N-acetylneuraminic acid (sialic acid) residues existing on the plasmamembrane surface of lymphocytes to induce their proliferation. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:00:14