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Titolo:
Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells
Autore:
Shin, JS; Lee, JJ; Kim, Y; Lee, CK; Yun, YP; Lee, MK;
Indirizzi:
Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea Chungbuk NatlUniv Cheongju South Korea 361763 ongju 361763, South Korea
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 1, volume: 24, anno: 2001,
pagine: 103 - 105
SICI:
0918-6158(200101)24:1<103:IEOEAH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; TYROSINE-HYDROXYLASE; MONOAMINE-OXIDASE; BIOSYNTHESIS; HIGENAMINE; PLASMA; ASSAY;
Keywords:
ethaverine; dopamine content; tyrosine hydroxylase; PC12 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, MK Chungbuk Natl Univ, Coll Pharm, San 48, Cheongju 361763, South Korea Chungbuk Natl Univ San 48 Cheongju South Korea 361763 South Korea
Citazione:
J.S. Shin et al., "Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells", BIOL PHAR B, 24(1), 2001, pp. 103-105

Abstract

The inhibitory effects of ethaverine on dopamine content in PC12 cells a ere investigated. Ethaverine decreased dopamine content in a concentration-dependent manner in PC12 cells and showed 33.6% inhibition of dopamine content at a concentration of 1.0 muM for 24-48 h. The IC50 value of ethaverine was 1.4 muM. Dopamine content was lowered at 6 h and reached a minimal level at 12 h after exposure to ethaverine at 2.0 muM. The decreased dopamine level was maintained up to 48 h and then recovered to the control level at about 72 h. Tyrosine hydroxylase (TH) was inhibited at 6 h following treatment with ethaverine in PC12 cells and the activity was maintained at a reduced level up to 36 h (12-22% inhibition at 2.0 muM). These results indicate that ethaverine leads to a decrease in dopamine content by inhibition of THactivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:09:44