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Titolo:
Effects of peppermint (Mentha piperita L.) extracts on experimental allergic rhinitis in rats
Autore:
Inoue, T; Sugimoto, Y; Masuda, H; Kamei, C;
Indirizzi:
Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, Okayama 7008530, Japan Okayama Univ Okayama Japan 7008530 ept Pharmacol, Okayama 7008530, Japan Ogawa & Co Ltd, Mat R&D Lab, Chiba 2790032, Japan Ogawa & Co Ltd Chiba Japan 2790032 td, Mat R&D Lab, Chiba 2790032, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 1, volume: 24, anno: 2001,
pagine: 92 - 95
SICI:
0918-6158(200101)24:1<92:EOP(PL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Keywords:
Mentha piperita L.; histamine release; sneezing; nasal rubbing; experimental allergic model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Kamei, C Okayama Univ, Fac Pharmaceut Sci, Dept Pharmacol, 1-1-1 Tsushima Naka, Okayama 7008530, Japan Okayama Univ 1-1-1 Tsushima Naka Okayama Japan 7008530 30, Japan
Citazione:
T. Inoue et al., "Effects of peppermint (Mentha piperita L.) extracts on experimental allergic rhinitis in rats", BIOL PHAR B, 24(1), 2001, pp. 92-95

Abstract

The present study,vas carried out to clarify the effects of extracts of the leaves of Mentha piperita L. on experimental allergic rhinitis. The 50% EtOH extract of peppermint inhibited histamine release from rat peritoneal mast cells induced by compound 48/80. The effect was dose-dependent and significant inhibition was observed at a concentration of 3 mug/ml. In addition, the 50% EtOH eluate separated from the 50% EtOH extract of peppermint by column chromatography (DIAION HP-20) was also effective in inhibiting histamine release at a concentration of 1 mug/ml. Nasal symptoms, sneezing and nasal rubbing induced by antigen challenge in actively sensitized rats were inhibited by oral administration of the 50% EtOH eluate. Significant inhibition of sneezing and nasal rubbing was observed at doses of 300 and 1000 mg/kg, p.o., respectively: Furthermore, the 50% EtOH eluate inhibited die leakage into the nasal cavity of rats induced by antigen in a dose-dependent manner. These results suggested that extracts of Mentha piperita L. may be clinically effective in alleviating the nasal symptoms of allergic rhinitis.

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Documento generato il 05/04/20 alle ore 13:03:07