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Titolo:
Na+ and K+ dependence of L-glutamate-induced suppression of astrocyte stellation in culture
Autore:
Abe, K; Saito, H;
Indirizzi:
Univ Tokyo, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Dept Chem Pharmacol, Tokyo 1130033, Japan Hoshi Univ, Sch Pharm, Dept Pharmacol, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 arm, Dept Pharmacol, Tokyo 1428501, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 1, volume: 24, anno: 2001,
pagine: 50 - 53
SICI:
0918-6158(200101)24:1<50:NAKDOL>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT CORTICAL ASTROCYTES; BLOOD-BRAIN-BARRIER; STIMULATED STELLATION; ALZHEIMERS-DISEASE; REACTIVE GLIOSIS; TRANSPORTER; SHAPE; EXPRESSION; THROMBIN; CELLS;
Keywords:
astrocyte; morphology; L-glutamate; glutamate transporter; ouabain; culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, K Univ Tokyo, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tokyo 1130033,Japan Univ Tokyo Tokyo Japan 1130033 em Pharmacol, Tokyo 1130033, Japan
Citazione:
K. Abe e H. Saito, "Na+ and K+ dependence of L-glutamate-induced suppression of astrocyte stellation in culture", BIOL PHAR B, 24(1), 2001, pp. 50-53

Abstract

We have recently found that L-glutamate suppresses astrocyte stellation induced by various stimuli, and that this effect of L-glutamate is mimicked by transportable glutamate uptake inhibitors. To test the possible role of the glutamate transporter in the regulation of astrocyte morphology, we investigated the Na+ and K+ dependence of this effect of L-glutamate. In astrocyte cultures obtained from the cerebral cortex of neonatal rats, the L-glutamate-induced suppression of astrocyte stellation was significantly attenuated in a low-Na+/high-K+ medium and by the Na+-K+ pump inhibitor ouabain. These results support that astrocyte morphology is affected by the activity of the Na+-dependent glutamate transporter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:26:31