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Titolo:
SP-40,40 is a component of plasminogen activator inhibitor-1-binding protein and stabilizes plasminogen activator inhibitor-1 activity
Autore:
Choi-Miura, NH;
Indirizzi:
Showa Univ, Sch Pharmaceut Sci, Dept Physiol Chem, Shinagawa Ku, Tokyo 1428555, Japan Showa Univ Tokyo Japan 1428555 Chem, Shinagawa Ku, Tokyo 1428555, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 1, volume: 24, anno: 2001,
pagine: 39 - 42
SICI:
0918-6158(200101)24:1<39:SIACOP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE ATTACK COMPLEX; HUMAN S-PROTEIN; BETA-ENDORPHIN; HUMAN-PLASMA; SULFATED GLYCOPROTEIN-2; MOLECULAR-CLONING; BINDING-PROTEIN; GENE-EXPRESSION; SEMINAL PLASMA; TESTIS FLUID;
Keywords:
clusterin; PAI-1; vitronectin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Choi-Miura, NH Showa Univ, Sch Pharmaceut Sci, Dept Physiol Chem, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan Showa Univ 1-5-8 Hatanodai Tokyo Japan 1428555 8555, Japan
Citazione:
N.H. Choi-Miura, "SP-40,40 is a component of plasminogen activator inhibitor-1-binding protein and stabilizes plasminogen activator inhibitor-1 activity", BIOL PHAR B, 24(1), 2001, pp. 39-42

Abstract

A complex of plasminogen activator inhibitor-1 (PAI-1) and PAI-1-binding protein (PAI-I-BP) contained S-protein (vitronectin), PAI-1 and unidentified40-kDa protein on SDS-PAGE under reducing conditions. By Western-blot analysis, the 40-kDa protein was identified as SP-40,40 using anti-SP-40,40 antibody. Therefore, it was thought that PAI-1-BP consisted of S-protein and SP-40,40. It is known that PAI-l is a labile protein which becomes inactive during incubation at 37 degreesC. However, after the incubation of PAI-1 with SP-40,40 at 37 degreesC for 1 h, PAI-1 could still form a complex with tissue plasminogen activator (tPA), and it inhibited plasmin formation in the mixture of plasminogen and urine plasminogen activator (uPA). The resultsclearly indicated that SP-40,40 stabilized PAI-1 activity as well as S-protein did.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:32:52