Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response
Autore:
Dirks, A; Pattij, T; Bouwknecht, JA; Westphal, TT; Hijzen, TH; Groenink, L; van der Gugten, J; Oosting, RS; Hen, R; Geyer, MA; Olivier, B;
Indirizzi:
Univ Utrecht, Dept Psychopharmacol, NL-3584 CA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands Univ Utrecht, Dept Pharmaceut Proteom, NL-3584 CA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 CA 3584 CA Utrecht, Netherlands Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ New York NY USA 10032 obiol & Behav, New York, NY 10032 USA Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 118, anno: 2001,
pagine: 169 - 178
SICI:
0166-4328(20010129)118:2<169:5RKBN5>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEAR-POTENTIATED STARTLE; SEROTONIN RECEPTOR; PREPULSE INHIBITION; ANIMAL-MODEL; OUT MICE; RATS; ANXIETY; HABITUATION; LACKING; SCHIZOPHRENIA;
Keywords:
acoustic startle response; 5-HT1A receptor; 5-HT1B receptor; prepulse inhibition; footshock-induced sensitization; habituation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Dirks, A Univ Utrecht, Dept Psychopharmacol, Sorbonnelaan 16, NL-3584 CA Utrecht, Netherlands Univ Utrecht Sorbonnelaan 16 Utrecht Netherlands NL-3584 CA ands
Citazione:
A. Dirks et al., "5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response", BEH BRA RES, 118(2), 2001, pp. 169-178

Abstract

To investigate whether the hyperreactivity to mild environmental and novelstimuli in 5-HT1B receptor knockout (1BKO) mice, as suggested by measures of exploratory, aggressive, and impulsive behaviors, can be extended to phasic stimuli, 1BKO and wildtype mice were tested in acoustic startle reactivity and plasticity paradigms, including habituation, prepulse inhibition, and footshock-induced sensitization of the startle response. Furthermore, wecompared 5-HT1A receptor knockout (1AKO) and 1BKO mice to further test thesuggested opposite behavioral profiles in these two genotypes. Results show that startle reactivity and Footshock-induced sensitization was reduced in 1BKO mice, with no changes in habituation or PPI. In contrast, 1AKO mice did not differ from WT mice in any of the measures. These results indicate that an absence of 5-HT1B receptors, but not of 5-HT1A receptors, affects the modulation of startle reactivity and footshock-induced sensitization, without influencing startle plasticity. Moreover, this study suggests that 1AKO mice display a distinct, but not opposite behavioral profile from 1BKO mice. Furthermore, it is concluded that the hyperreactivity in 1BKO mice cannot be generalized to all stimuli, including the startling stimuli used in this study, but is probably restricted to mild environmental stimuli only. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:26:46