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Titolo:
Exhaustion of the coital reflex in spinal male rats is reversed by the serotonergic agonist 8-OH-DPAT
Autore:
Carro-Juarez, M; Rodriguez-Manzo, G;
Indirizzi:
CINVESTAV, IPN, Dept Farmacobiol & Toxicol, Mexico City 14000, DF, Mexico CINVESTAV Mexico City DF Mexico 14000 icol, Mexico City 14000, DF, Mexico Univ Autonoma Tlaxcala, Escuela Med Vet & Zootecnia, Unidad Posgrado, Tlaxcala 90000, Mexico Univ Autonoma Tlaxcala Tlaxcala Mexico 90000 ado, Tlaxcala 90000, Mexico Inst Mexicano Psiquiatria, Div Invest Neurociencias, Mexico City, DF, Mexico Inst Mexicano Psiquiatria Mexico City DF Mexico Mexico City, DF, Mexico
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 118, anno: 2001,
pagine: 161 - 168
SICI:
0166-4328(20010129)118:2<161:EOTCRI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASCULINE SEXUAL-BEHAVIOR; EJACULATORY BEHAVIOR; INHIBITORY-ACTION; 5-HT1B RECEPTORS; PENILE REFLEXES; 5-HYDROXYTRYPTAMINE; INVOLVEMENT; STIMULATION; LESIONS;
Keywords:
coital reflex; 8-OH-DPAT; ejaculation; masculine sexual function; sexual exhaustion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Rodriguez-Manzo, G CINVESTAV, IPN, Dept Farmacobiol & Toxicol, POB 22026, Mexico City 14000, DF, Mexico CINVESTAV POB 22026 Mexico City DF Mexico 14000 Mexico
Citazione:
M. Carro-Juarez e G. Rodriguez-Manzo, "Exhaustion of the coital reflex in spinal male rats is reversed by the serotonergic agonist 8-OH-DPAT", BEH BRA RES, 118(2), 2001, pp. 161-168

Abstract

Previous studies from our laboratory have shown that the genital motor pattern associated to the coital reflex in spinal male rats becomes exhausted when repeatedly evoked. Exhaustion of the genital motor pattern could be related to the sexual exhaustion phenomenon observed in copulating male rats. The present study was aimed to describe the features of coital reflex exhaustion and to determine if the 5-HT1A agonist 8-OH-DPAT was able to reverseexhaustion of this ejaculatory-like response. Additionally, the effect of pre-treatment with the 5-HT1A antagonist WAY 100635 on the 8-OH-DPAT induced motor response was evaluated. Results revealed that development of coitalreflex exhaustion initiated with a progressive increase in the latency of response and was characterised by a change in the properties of the motor pattern itself. Once exhausted, i.v. administration of 8-OH-DPAT provoked the immediate expression of a potent motor pattern similar to the coital reflex, but in the absence of urethral stimulation. Injection of WAY 100635 induced, per se, expression of the coital reflex after exhaustion. Notwithstanding, pre-treatment with WAY 100635 was able to block, the 8-OH-DPAT-induced motor response implying that its effect was exerted upon 5-HT1A receptors. Data suggest that the sexual exhaustion phenomenon might possess a spinalcomponent. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:32:15