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Titolo:
Nucleus accumbens, entorhinal cortex and latent inhibition: A neural network model
Autore:
Schmajuk, NA; Cox, L; Gray, JA;
Indirizzi:
Duke Univ, Dept Expt Psychol, Durham, NC 27706 USA Duke Univ Durham NC USA 27706 iv, Dept Expt Psychol, Durham, NC 27706 USA Inst Psychiat, Dept Psychol, London SE5 8AF, England Inst Psychiat London England SE5 8AF pt Psychol, London SE5 8AF, England
Titolo Testata:
BEHAVIOURAL BRAIN RESEARCH
fascicolo: 2, volume: 118, anno: 2001,
pagine: 123 - 141
SICI:
0166-4328(20010129)118:2<123:NAECAL>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; NICTITATING-MEMBRANE RESPONSE; MONKEY DOPAMINE NEURONS; CHOLINERGIC NEURONS; STIMULUS CONFIGURATION; SUBSTANTIA-NIGRA; SWITCHING MODEL; BASAL GANGLIA; SCHIZOPHRENIA; RATS;
Keywords:
latent inhibition; neural network; dopamine; haloperidol; nucleus accumbens; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Schmajuk, NA Duke Univ, Dept Expt Psychol, POB 90086, Durham, NC 27706 USADuke Univ POB 90086 Durham NC USA 27706 Durham, NC 27706 USA
Citazione:
N.A. Schmajuk et al., "Nucleus accumbens, entorhinal cortex and latent inhibition: A neural network model", BEH BRA RES, 118(2), 2001, pp. 123-141

Abstract

A neural network model of classical conditioning (Schmajuk, Lam, and Gray,J. Exp. Psychol.: Anim. Behav. Process, 22, 1996, 321-349) is applied to the description of the neural substrates of latent inhibition. Experimental data suggest that latent inhibition might be controlled by a circuit that involves the hippocampus, the entorhinal cortex, the nucleus accumbens, and the mesolimbic dopaminergic projection from the ventral tegmental area to the accumbens. By mapping different nodes and connections in the model onto this brain circuit, computer simulations demonstrate that, in most cases, the model provides a good quantitative description of: (1) the impairment oflatent inhibition by lesions of the shell of the nucleus accumbens; (2) the restoration of latent inhibition by haloperidol following lesions of the shell; (3) the preservation of latent inhibition by lesions of the core of the nucleus accumbens; (4) the facilitation of latent inhibition by combined shell core lesions and by core lesions with extended conditioning; (5) the impairment of latent inhibition following lesions of the entorhinal cortex or the hippocampus; and (6) the restoration of latent inhibition by haloperidol following lesions of the entorhinal cortex and ventral subiculum. Inaddition, the model is able to describe neural activity in the nucleus accumbens. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:08:23