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Titolo:
Monitoring regional cerebral oxygen saturation using near-infrared spectroscopy during pulsatile hypothermic cardiopulmonary bypass in a neonatal piglet model
Autore:
Undar, A; Eichstaedt, HC; Frazier, OH; Fraser, CD;
Indirizzi:
Texas Childrens Hosp, Congenital Heart Serv, Houston, TX 77030 USA Texas Childrens Hosp Houston TX USA 77030 art Serv, Houston, TX 77030 USA Texas Heart Inst, Cullen Cardiovasc Surg Res Lab, Houston, TX 77025 USA Texas Heart Inst Houston TX USA 77025 Surg Res Lab, Houston, TX 77025 USA Baylor Coll Med, Dept Surg, Houston, TX 77030 USA Baylor Coll Med HoustonTX USA 77030 ed, Dept Surg, Houston, TX 77030 USA Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 , Dept Pediat, Houston, TX 77030 USA
Titolo Testata:
ASAIO JOURNAL
fascicolo: 1, volume: 46, anno: 2000,
pagine: 103 - 106
SICI:
1058-2916(200001/02)46:1<103:MRCOSU>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDIATRIC CARDIAC-SURGERY; SYSTEM; PERFUSION; CHILDREN; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Undar, A Texas Childrens Hosp, Congenital Heart Serv, 6621 Fannin St,MC 1-2285, Houston, TX 77030 USA Texas Childrens Hosp 6621 Fannin St,MC 1-2285 Houston TX USA 77030
Citazione:
A. Undar et al., "Monitoring regional cerebral oxygen saturation using near-infrared spectroscopy during pulsatile hypothermic cardiopulmonary bypass in a neonatal piglet model", ASAIO J, 46(1), 2000, pp. 103-106

Abstract

Impairment of cerebral oxygenation in neonates and infants after hypothermic nonpulsatile cardiopulmonary bypass (CPB) support is well documented. The objectives of this study were: 1) using a neonatal piglet model to continuously monitor the regional cerebral oxygen saturation (rSO(2)) by near-infrared spectroscopy during pulsatile hypothermic CPB; and 2) to quantify thepulsatile flow in terms of energy equivalent pressure (EEP). After initiation of CPB, all piglets (n = 5) were subjected to 15 minutes of core cooling, reducing the rectal temperature to 25 degreesC, followed by 60 minutes of hypothermic CPB, then 10 minutes of cold reperfusion, and 30 minutes of rewarming. During CPB, mean arterial pressures (MAPs) and pump flow rates were maintained at 40-45 mm Hg and 150 ml/kg/min, respectively. During normothermic CPB, the rSO(2) was significantly increased, compared with the pre-CPB level (56.8 +/- 5.2% vs. 41.8 +/- 5.5%, p < 0.01). At the end of cooling, the rSO(2) level was 76.8 +/- 8.6% (p < 0.001 vs. pre-CPB). After 60 minutes of hypothermic CPB and 30 minutes of rewarming, the rSO(2) level was decreased to 38.6 +/- 4.2%, which was not significantly different compared with the pre-CPB level. The average increase in pressure (from MAP to EEP was5 +/- 1%, and the average increase in extracorporeal circuit pressure (from ECCP to EEP) was 13 +/- 2%. This extra pressure may help to provide better regional cerebral oxygen saturation. During pulsatile CPB, there was no rSO(2) deficiency in this high flow model. Near-infrared spectroscopy responded well to changes in rSO(2) during different stages of these experiments and might be a helpful tool for intraoperative monitoring.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/12/18 alle ore 00:37:11