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Titolo:
I: Negative effect of cold ischemia on initial renal function
Autore:
Stubenitsky, BM; Booster, MH; Brasile, L; Green, EM; Hermens, FHW; Stroosma, OB; Kootstra, G;
Indirizzi:
AZM Univ Hosp Maastricht, Dept Surg, Preservat Res Grp, NL-6202 AZ Maastricht, Netherlands AZM Univ Hosp Maastricht Maastricht Netherlands NL-6202 AZ , Netherlands Breon Inc, Schenectady, NY USA Breon Inc Schenectady NY USABreon Inc, Schenectady, NY USA
Titolo Testata:
ASAIO JOURNAL
fascicolo: 1, volume: 46, anno: 2000,
pagine: 60 - 61
SICI:
1058-2916(200001/02)46:1<60:INEOCI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Stubenitsky, BM AZM Univ Hosp Maastricht, Dept Surg, Preservat Res Grp, POB 5800, NL-6202 AZ Maastricht, Netherlands AZM Univ Hosp Maastricht POB 5800 Maastricht Netherlands NL-6202 AZ
Citazione:
B.M. Stubenitsky et al., "I: Negative effect of cold ischemia on initial renal function", ASAIO J, 46(1), 2000, pp. 60-61

Abstract

Correlation between post-transplant function and exposure to cold ischemia(CI) during preservation has been reported. We attempted to identify the effect of CI on renal function using exsanguinous metabolic support (EMS) technology, to eliminate effects of reperfusion complications. Small bovine kidneys were used to evaluate 4 vs. 24 hours of CI, after warm ischemic (WI)exposure of <15, 30 or 60 minutes. After CI, kidneys were warm perfused (30<degrees>C to 32 degreesC) ex vivo using EMS technology. Restored renal metabolism and function were quantified by oxygen consumption, urine production, glomerular filtration rate (GFR), and hemodynamic characteristics. The results demonstrate a CI-associated lag phase in the restoration of metabolism, in which the longer cold-preserved kidneys exhibit a lower initial rate of oxygen consumption. However, after 3 hours of EMS perfusion there was no significant difference in the O-2 consumed, urine flow, GFR, perfusion flow, or pressure between the kidneys stored for 4 or 24 hours. An initial reduction in metabolism after longer CI may influence the severity of actualreperfusion injury during transplantation. Therefore, these results provide preliminary evidence suggesting that an acellular warm temperature reperfusion ex vivo may enhance restoration of cellular metabolism and minimize damage from the cold seen upon actual reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:20:08