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Titolo:
Perspectives in pharmacogenetics
Autore:
Kalow, W;
Indirizzi:
Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 macol, Toronto, ON M5S 1A8, Canada
Titolo Testata:
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
fascicolo: 1, volume: 125, anno: 2001,
pagine: 77 - 80
SICI:
0003-9985(200101)125:1<77:PIP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFECTIVE N-OXIDATION; DRUG-METABOLISM; DEBRISOQUINE; 4-HYDROXYLATION; RESISTANCE; SPARTEINE; ALLELES; SNPS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kalow, W Univ Toronto, Dept Pharmacol, Med Sci Bldg, Toronto, ON M5S 1A8, Canada Univ Toronto Med Sci Bldg Toronto ON Canada M5S 1A8 S 1A8, Canada
Citazione:
W. Kalow, "Perspectives in pharmacogenetics", ARCH PATH L, 125(1), 2001, pp. 77-80

Abstract

The historical perspective of pharmacogenetics is presented to a large extent from a personal view since I happened to get into this field of scienceat the time of its beginning, and since pharmacogenetics has remained the backbone of my scientific career. Pharmacogenetics initially emphasized observations of interpersonal variability, but the attention on interethnic differences soon followed. Technical advances led to the identification of many responsible gene alterations in both individuals and in populations. Included is a relatively extensive discussion in which the effects and the different consequences of monogenic (mendelian) and multigenic (multifactorial) variation are compared.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 15:18:31