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Titolo:
A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis
Autore:
Pelletier, J; Suchet, L; Witjas, T; Habib, M; Guttmann, CRG; Salamon, G; Lyon-Caen, O; Cherif, AA;
Indirizzi:
CHU Timone, Dept Neurol, F-13385 Marseille 5, France CHU Timone Marseille France 5 , Dept Neurol, F-13385 Marseille 5, France Univ Hosp Marseilles, Dept Neurol, Marseille, France Univ Hosp MarseillesMarseille France s, Dept Neurol, Marseille, France Univ Hosp Marseilles, Dept Neuroradiol, Marseille, France Univ Hosp Marseilles Marseille France pt Neuroradiol, Marseille, France Univ Marseilles, INSERM, E 9926, Neurophysiol & Neuropsychol Unit, Marseille, France Univ Marseilles Marseille France & Neuropsychol Unit, Marseille, France Univ Hosp Salpetriere Paris, Fed Neurol, Paris, France Univ Hosp Salpetriere Paris Paris France ris, Fed Neurol, Paris, France Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Radiol, Boston, MA 02115 USA
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 1, volume: 58, anno: 2001,
pagine: 105 - 111
SICI:
0003-9942(200101)58:1<105:ALSOCA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLINICALLY ISOLATED SYNDROMES; APPEARING WHITE-MATTER; MAGNETIC-RESONANCE; CORPUS-CALLOSUM; INTERFERON BETA-1A; EVOKED-POTENTIALS; BRAIN ATROPHY; MRI; DISABILITY; IMPAIRMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Pelletier, J CHU Timone, Dept Neurol, F-13385 Marseille 5, France CHU Timone Marseille France 5 , F-13385 Marseille 5, France
Citazione:
J. Pelletier et al., "A longitudinal study of callosal atrophy and interhemispheric dysfunction in relapsing-remitting multiple sclerosis", ARCH NEUROL, 58(1), 2001, pp. 105-111

Abstract

Objectives: To determine if callosal atrophy and interhemispheric dysfunction can be detected in the early stages of relapsing-remitting, multiple sclerosis (MS) and to evaluate their progression in relation to the disability and evolution of lesions seen on magnetic resonance imaging during a 5-year period. Methods: We compared 30 patients who had clinically definite early-onset replasing-remitting MS and mild disability with control subjects. Regional and segmental callosal size and extent of white matter abnormalities on magnetic resonance imaging, as well as performance on tasks exploring interhemispheric transfer of motor, auditory, and sensory information were assessed. Patients with MS were evaluated at baseline and after 5 years. Physical disability was determined at both rimes using the Expanded Disability Status Scale score. Results: Patients with MS were seen with significant callosal atrophy and functional impairment of interhemispheric transfer at baseline that worsened during the 5-year study. A significant correlation was found between the mag nitude of disability and the severity of morphological and functional callosal involvement at baseline. This association persisted at rear 5. Baseline clinical characteristics such as age and prestudy relapse rate were unrelated to callosal size or interhemispheric performance. However, the number of baseline T2-weighted lesions was correlated with callosal involvementand this relation persisted at year 5. Conclusion: Patients who had relapsing-remitting MS in the early stages ofthe disease and mild disability had significant callosal involvement that progressed over time. The relationship between disability, T2-weighted lesions load, and degree of morphological and functional callosal impairment confirm the potential value of using callosal dysfunction as a surrogate marker of disease progression in MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:40:56