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Titolo:
Volumes of brain structures in twins discordant for schizophrenia
Autore:
Baare, WFC; van Oel, CJ; Pol, HEH; Schnack, HG; Durston, S; Sitskoorn, MM; Kahn, RS;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Psychiat, NL-3584 CX Utrecht, Netherlands UnivUtrecht Utrecht Netherlands NL-3584 CX 3584 CX Utrecht, Netherlands
Titolo Testata:
ARCHIVES OF GENERAL PSYCHIATRY
fascicolo: 1, volume: 58, anno: 2001,
pagine: 33 - 40
SICI:
0003-990X(200101)58:1<33:VOBSIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOTYPAL PERSONALITY-DISORDER; VENTRICULAR ENLARGEMENT; DIAGNOSTIC INTERVIEW; ABNORMALITIES; PSYCHOSES; SIBLINGS; MOTHERS; SIZE; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kahn, RS Univ Utrecht, Med Ctr, Dept Psychiat, Heidelberglaan 100, NL-3584CX Utrecht, Netherlands Univ Utrecht Heidelberglaan 100 Utrecht Netherlands NL-3584 CX s
Citazione:
W.F.C. Baare et al., "Volumes of brain structures in twins discordant for schizophrenia", ARCH G PSYC, 58(1), 2001, pp. 33-40

Abstract

Background: The study was designed to examine the relative contributions of genetic and nongeneric factors to structural brain abnormalities in schizophrenia and subjects at risk to develop the disorder. Methods: The brains of 15 monozygotic and 14 same-sex dizygotic twins discordant for schizophrenia (patients) and 29 healthy twins pair-wise matched for zygosity, sex, age, and birth order were st studied using high-resolution magnetic resonance imaging scans. Results: Intracranial and whole-brain corrected frontal lobe volumes were smaller (4.6% and 2.7%, respectively) in discordant monozygotic twins as compared with healthy monozygotic twins. Irrespective of zygosity, discordanttwins had smaller whole-brain (2%), parahippocampal (9%), and hippocampal (8%) volumes than healthy twins. Moreover, patients had smaller whole-brainvolumes (2.2%) than their nonschizophrenic cotwins, who in turn had smaller brains (1%) than healthy twins. Lateral and third-ventricle volumes were increased in discordant dizygotic twins as compared with healthy dizygotic twins (60.6% and 56.6%, respectively). Finally, within discordant twins, lateral ventricles were larger (14.4%) in patients than in their nonschizophrenic cotwins. Conclusions: Smaller intracranial volumes in the monozygotic patients and their cotwins suggest that increased genetic risk to develop schizophrenia is related to reduced brain growth early in life. The additional reduction in whole-brain Volume found in the patients suggests that the manifestationof the disorder is related to (neurodegenerative) processes that are most likely nongenetic in origin.

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Documento generato il 21/01/20 alle ore 01:07:25