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Titolo:
Transcription of eukaryotic protein-coding genes
Autore:
Lee, TI; Young, RA;
Indirizzi:
MIT, Dept Biol, Cambridge, MA 02139 USA MIT Cambridge MA USA 02139MIT, Dept Biol, Cambridge, MA 02139 USA Whitehead Inst Biomed Res, Cambridge, MA 02142 USA Whitehead Inst Biomed Res Cambridge MA USA 02142 Cambridge, MA 02142 USA
Titolo Testata:
ANNUAL REVIEW OF GENETICS
, volume: 34, anno: 2000,
pagine: 77 - 137
SICI:
0066-4197(2000)34:<77:TOEPG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RNA-POLYMERASE-II; TATA-BINDING PROTEIN; C-TERMINAL DOMAIN; START SITE SELECTION; NUCLEAR RECEPTOR COACTIVATOR; GLOBAL-NEGATIVE REGULATOR; KINASE-ACTIVATING KINASE; CYCLIN-DEPENDENT KINASES; CORE PROMOTER STRUCTURE; LOCUS-CONTROL REGIONS;
Keywords:
gene expression; RNA polymerase II holoenzyme; Srb/mediator complex; chromatin modification; activation and repression;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
246
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, TI MIT, Dept Biol, 77 Massachusetts Ave, Cambridge, MA 02139 USA MIT 77 Massachusetts Ave Cambridge MA USA 02139 idge, MA 02139 USA
Citazione:
T.I. Lee e R.A. Young, "Transcription of eukaryotic protein-coding genes", ANN R GENET, 34, 2000, pp. 77-137

Abstract

The past decade has seen an explosive increase in information about regulation of eukaryotic gene transcription, especially for protein-coding genes. The most striking advances in our knowledge of transcriptional regulation involve the chromatin template, the large complexes recruited by transcriptional activators that regulate chromatin structure and the transcription apparatus, the holoenzyme forms of RNA polymerase II involved in initiation and elongation, and the mechanisms that link mRNA processing with its synthesis. We describe here the major advances in these areas, with particular emphasis on the modular complexes associated with RNA polymerase II that are targeted by activators and other regulators of mRNA biosynthesis.

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Documento generato il 27/10/20 alle ore 04:35:38