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Titolo:
Multicenter study of principles-based waveforms for external defibrillation
Autore:
Bain, AC; Swerdlow, CD; Love, CJ; Ellenbogen, KA; Deering, TF; Brewer, JE; Augostini, RS; Tchou, PJ;
Indirizzi:
Survivalink Corp, Minneapolis, MN USA Survivalink Corp Minneapolis MN USA urvivalink Corp, Minneapolis, MN USA Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Ohio State Univ, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 State Univ, Columbus, OH 43210 USA Med Ctr Virginia, Richmond, VA USA Med Ctr Virginia Richmond VA USAMed Ctr Virginia, Richmond, VA USA Pacemaker Surveillance Clin, Atlanta, GA USA Pacemaker Surveillance Clin Atlanta GA USA illance Clin, Atlanta, GA USA Cleveland Clin Fdn, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 in Fdn, Cleveland, OH 44195 USA
Titolo Testata:
ANNALS OF EMERGENCY MEDICINE
fascicolo: 1, volume: 37, anno: 2001,
pagine: 5 - 12
SICI:
0196-0644(200101)37:1<5:MSOPWF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPHASIC WAVE-FORMS; HOSPITAL CARDIAC-ARREST; TRANSTHORACIC DEFIBRILLATION; VENTRICULAR-FIBRILLATION; MINIMAL MODEL; DAMPED SINE; SHOCKS; EFFICACY; ENERGY; CARDIOVERSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Bain, AC 5420 Feltl Rd, Minneapolis, MN 55343 USA 5420 Feltl Rd Minneapolis MN USA 55343 Minneapolis, MN 55343 USA
Citazione:
A.C. Bain et al., "Multicenter study of principles-based waveforms for external defibrillation", ANN EMERG M, 37(1), 2001, pp. 5-12

Abstract

Study objective: The efficacy of a shock waveform for external defibrillation depends on the waveform characteristics. Recently, design principles based on cardiac electrophysiology have been developed to determine optimal waveform characteristics. The objective of this clinical trial was to evaluate the efficacy of principles-based monophasic and biphasic waveforms for external defibrillation. Methods: A prospective, randomized, blinded, multicenter study of 118 patients undergoing electrophysiologic testing or receiving an implantable defibrillator was conducted. Ventricular fibrillation was induced, and defibrillation was attempted in each patient with a biphasic and a monophasic waveform. Patients were randomly placed into 2 groups: group 1 received shocks of escalating energy, and group 2 received only high-energy shocks. Results: The biphasic waveform achieved a first-shock success rate of 100%in group 1 (95% confidence interval [CI] 95.1% to 100%) and group 2 (95% CI 94.6% to 100%), with average delivered energies of 201+/-17 J and 295+/-28 J, respectively. The monophasic waveform demonstrated a 96.7% (95% CI 89.1% to 100%) first-shock success rate and average delivered energy of 215+/-12 J for group 1 and a 98.2% 195% CI 91.7% to 100%) first-shock success rate and average delivered energy of 352+/-13 J for group 2. Conclusion: Using principles of electrophysiology, it is possible to design both biphasic and monophasic waveforms for external defibrillation that achieve a high first-shock efficacy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:35:43