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Titolo:
Changing synaptic connections an cell bodies of growing identified spinal motoneurons of the eel, Anguilla
Autore:
Smit, WA; Velzing, EH; Diegenbach, PC; Roberts, BL;
Indirizzi:
Univ Dublin Trinity Coll, Dept Zool, Dublin 2, Ireland Univ Dublin TrinityColl Dublin Ireland 2 , Dept Zool, Dublin 2, Ireland Univ Amsterdam, Ctr Biol, Inst Neurobiol, Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands Neurobiol, Amsterdam, Netherlands
Titolo Testata:
ANATOMY AND EMBRYOLOGY
fascicolo: 2, volume: 203, anno: 2001,
pagine: 129 - 136
SICI:
0340-2061(200102)203:2<129:CSCACB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOTOR-NERVE TERMINALS; POSTNATAL-GROWTH; NEUROMUSCULAR-JUNCTIONS; TRANSMITTER RELEASE; SIZE; MUSCLE; MOUSE; ZEBRAFISH; NUMBER; FROG;
Keywords:
spinal cord; neuron size; synaptogenesis; plasticity; growth;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, BL Univ Dublin Trinity Coll, Dept Zool, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 Dublin 2, Ireland
Citazione:
W.A. Smit et al., "Changing synaptic connections an cell bodies of growing identified spinal motoneurons of the eel, Anguilla", ANAT EMBRYO, 203(2), 2001, pp. 129-136

Abstract

As the target musculature they innervate grows throughout life, certain segmental motoneurons from the spinal cord of Anguilla, readily identified onthe basis of their form and position, also increase in size. In doing so, they present a steadily increasing target to the spinal and supraspinal neurons that innervate them. How the afferent neurons respond was assessed by measuring features of their synaptic boutons contacting the motoneuronal perikarya, as seen with electron microscopy. About 60% of the perimeter of the perikaryal profile of each motoneuron was found to be covered with synaptic bouton profiles, a value that is independent of the size of the motoneuron. Furthermore, the distances between synaptic profiles, their contact sizes (measured as apposition length) and the number and size of the vesicles each profile contains were all found to be relatively constant and also independent of motoneuronal size. In contrast, the number of synaptic profilescontacting a motoneuron correlated well with its perikaryal size. Our findings indicate that the challenge of a growing neuronal target is met by a steady increase in the number of contacting boutons, the form and spacing ofwhich are held relatively constant; this strategy will require continual synaptic realignment at the target.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 19:38:31