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Titolo:
Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex
Autore:
Soleimani, M; Greeley, T; Petrovic, S; Wang, ZH; Amlal, H; Kopp, P; Burnham, CE;
Indirizzi:
Univ Cincinnati, Dept Med, Div Nephrol & Hypertens, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 pertens, Cincinnati, OH 45267 USA Vet Affairs Med Ctr, Cincinnati, OH 45267 USA Vet Affairs Med Ctr Cincinnati OH USA 45267 Ctr, Cincinnati, OH 45267 USA Northwestern Univ, Dept Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 v, Dept Med, Chicago, IL 60611 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: F356 - F364
SICI:
0363-6127(200102)280:2<F356:PAACEI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORINEURAL HEARING-LOSS; LUMINAL NA+/H+ EXCHANGE; GENE ENCODES; ADENOMA DRA; FUNCTIONAL EXPRESSION; SULFATE TRANSPORTER; METABOLIC-ACIDOSIS; MEMBRANE-VESICLES; PROXIMAL TUBULE; BASE-EXCHANGE;
Keywords:
proximal tubule; cortical collecting duct; anion exchanger; apical membrane;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Soleimani, M Univ Cincinnati, Dept Med, Div Nephrol & Hypertens, 231 Bethesda Ave,MSB 5502, Cincinnati, OH 45267 USA Univ Cincinnati 231 Bethesda Ave,MSB 5502 Cincinnati OH USA 45267
Citazione:
M. Soleimani et al., "Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex", AM J P-REN, 280(2), 2001, pp. F356-F364

Abstract

The identities of the apical Cl-/base exchangers in kidney proximal tubuleand cortical collecting duct (CCD) cells remain unknown. Pendrin (PDS), which is expressed at high levels in the thyroid and its mutation causes Pendred's syndrome, is shown to be an anion exchanger. We investigated the renal distribution of PDS and its function. Our results demonstrate that pendrin mRNA expression in the rat kidney is abundant and limited to the cortex. Proximal tubule suspensions isolated from kidney cortex were highly enriched in pendrin mRNA. Immunoblot analysis studies localized pendrin to cortical brush-border membranes. Nephron segment RT-PCR localized pendrin mRNA to proximal tubule and CCD. Expression studies in HEK-293 cells demonstrated that pendrin functions in the Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange modes. The conclusion is that pendrin is an apical Cl-/base exchanger in thekidney proximal tubule and CCD and mediates Cl-/OH-, Cl-/HCO3-, and Cl-/formate exchange.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:29:10