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Titolo:
Mechanisms underlying renoprotection during renin-angiotensin system blockade
Autore:
Taal, MW; Chertow, GM; Rennke, HG; Gurnani, A; Jiang, T; Shahsafaei, A; Troy, JL; Brenner, BM; Mackenzie, HS;
Indirizzi:
Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Renal Div, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Dept Med,Renal Div, Boston, MA 02115 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: F343 - F355
SICI:
0363-6127(200102)280:2<F343:MURDRS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITORS; CHRONIC-RENAL-FAILURE; BLOOD-PRESSURE CONTROL; REMNANT KIDNEY MODEL; LIMITS GLOMERULAR INJURY; II RECEPTOR ANTAGONIST; DIABETIC NEPHROPATHY; PROGRESSIVE NEPHROPATHIES; INTERSTITIAL INFLAMMATION; MESANGIAL CELLS;
Keywords:
angiotensin-converting enzyme inhibitor; angiotensin receptor antagonist; glomerulosclerosis; systolic blood pressure; proteinuria; interleukin-1 beta; monocyte chemoattractant protein-1; transforming growth factor-beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Taal, MW Univ Calif San Francisco, Div Nephrol, 672 Hlth Sci E,Box 0532, San Francisco, CA 94143 USA Univ Calif San Francisco 672 Hlth Sci E,Box 0532San Francisco CA USA 94143
Citazione:
M.W. Taal et al., "Mechanisms underlying renoprotection during renin-angiotensin system blockade", AM J P-REN, 280(2), 2001, pp. F343-F355

Abstract

Potential determinants of chronic renal disease (CRD) progression were studied in male Munich-Wistar rats subjected to 5/6 nephrectomy and treated with candesartan (Csn; n = 30) or enalapril (Ena; n = 27) from 5 wk postsurgery. Despite control of systolic blood pressure (SBP; 24 wk: Csn = 143 +/- 9; Ena = 148 +/- 8 mmHg), urinary protein excretion rates (U-pr V) increasedover 24 wk (Csn = 92 +/- 10; Ena = 99 +/- 8mg/day). Glomerulosclerosis scores (GS) at 24 wk were similar for Csn (42 +/- 7%) vs. Ena (42 +/- 4%), values close to those of untreated controls at 12 wk (43 +/- 4%). At 24 wk, SBP and Upr V correlated strongly with GS, together accounting for 72% of thevariance in GS. Renal cortex mRNA levels (determined by competitive RT-PCR) for transforming growth factor (TGF)-beta1 and monocyte chemoattractant protein (MCP)-1 were elevated in Csn and Ena at 12 wk and remained higher at24 wk vs. sham. Strong correlations were evident among TGF-beta1, MCP-1, and interleukin-1 beta and renal injury at 24 wk. Cns and Ena are thus equally effective renoprotective agents in this model. During renin-angiotensin system inhibition, renoprotection is dependent on control of both SBP and U-pr V. Incomplete suppression of renal cytokine gene expression may also contribute to CRD progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:40:52