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Titolo:
Caffeine stores and dopamine differentially require Ca2+ channels in goldfish somatotropes
Autore:
Wong, CJH; Johnson, JD; Yunker, WK; Chang, JP;
Indirizzi:
Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada Univ Alberta Edmonton AB Canada T6G 2E9 Sci, Edmonton, AB T6G 2E9, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: R494 - R503
SICI:
0363-6119(200102)280:2<R494:CSADDR>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE RELEASE; BULLFROG SYMPATHETIC NEURONS; PURIFIED RAT SOMATOTROPHS; ADRENAL CHROMAFFIN CELLS; SENSITIVE CALCIUM STORES; PANCREATIC BETA-CELLS; INTRACELLULAR CALCIUM; PITUITARY-CELLS; RYANODINE RECEPTOR; PROTEIN-KINASE;
Keywords:
calcium-induced calcium release; adenosine 3 ',5 '-cyclic monophosphate; growth hormone; pituitary; secretion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Chang, JP Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada Univ Alberta Edmonton AB Canada T6G 2E9 ton, AB T6G 2E9, Canada
Citazione:
C.J.H. Wong et al., "Caffeine stores and dopamine differentially require Ca2+ channels in goldfish somatotropes", AM J P-REG, 280(2), 2001, pp. R494-R503

Abstract

The regulation of growth hormone (GH) secretion by intracellular Ca2+ stores was studied in dissociated goldfish somatotropes. We characterized a caffeine-activated intracellular store that had been shown to mediate GH release in response to gonadotropin-releasing hormone. The peak response of caffeine stimulation was reduced by similar to 28% by 100 muM ryanodine in a use-dependent manner suggesting that the first 10 min of GH release is partially mediated by a caffeine-activated ryanodine receptor. The temporal sensitivities of caffeine- and dopamine-evoked GH release to blockade of Cd2+-sensitive Ca2+ channels were compared. We demonstrated that the initial phaseof dopamine-evoked release was dependent on Ca2+ channels, whereas the initial phase of caffeine-evoked release was sensitive only to pretreatment blockade. This would suggest that the maintenance of one class of caffeine-activated intracellular stores requires entry of Ca2+ through Cd2+-sensitive Ca2+ channels. This differential temporal requirement for Ca2+ channels in Ca2+ signaling may be a mechanism to segregate intracellular signaling pathways of multiple neuroendocrine regulators in the teleost pituitary.

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Documento generato il 09/04/20 alle ore 20:12:50