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Titolo:
Angiotensin-(1-7) in the ovine fetus
Autore:
Moritz, KM; Campbell, DJ; Wintour, EM;
Indirizzi:
Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 arkville, Vic 3010, Australia St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia St Vincents Inst Med Res Fitzroy Vic Australia 3065 , Vic 3065, Australia
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: R404 - R409
SICI:
0363-6119(200102)280:2<R404:AITOF>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME; BRADYKININ PEPTIDES; NATRIURETIC ACTION; FETAL SHEEP; RAT; SYSTEM; STIMULATION; RECEPTOR; RELEASE;
Keywords:
angiotensin II; kidney; renin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Wintour, EM Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3010, Australia Univ Melbourne Parkville Vic Australia 3010 c 3010, Australia
Citazione:
K.M. Moritz et al., "Angiotensin-(1-7) in the ovine fetus", AM J P-REG, 280(2), 2001, pp. R404-R409

Abstract

In the adult animal, ANG-(1-7) may counterbalance some effects of ANG II. Its effects in the fetus are unknown. Basal ANG-(1-7), ANG I, ANG II, and renin concentrations were measured in plasma from ovine fetuses and their mothers (n = 10) at 111 days of gestation. In the fetus, concentrations of ANG I, ANG-(1-7), and ANG II were 86 +/- 21, 13 +/- 2, and 14 +/- 2 fmol/ml, respectively. In the ewe, concentrations of ANG I were significantly lower (20 +/- 4 fmol/ml, P< 0.05) as were concentrations of ANG-(1-7) (2.9 +/- 0.6 fmol/ml), whereas ANG II concentrations were not different (10 +/- 1 fmol/ml). Plasma renin concentrations were higher in the fetus (4.8 +/- 1.1 pmol ANG I.ml(-1).h(-1)) than in the ewe (0.9 +/- 0.2 pmol.ml(-1).h(-1), P< 0.05). Infusion of ANG-(1-7) (similar to9 mug/h) for a 3-day period caused a significant increase in plasma concentrations of ANG-(1-7) reaching a maximum of 448 +/- 146 fmol/ml on day 3 of infusion. Plasma levels of ANG I and II as well as renin were unchanged by the infusion. Urine flow rate, glomerular filtration rate, and fetal arterial blood pressure did not change and were not different than values in fetuses receiving a saline infusion for 3days (n = 5). However, the osmolality of amniotic and allantoic fluid was significantly higher in fetuses that received ANG-(1-7). Also, compared with the saline-infused animals, mRNA expression levels of renin, the AT(1) receptor, and AT(2) receptor were elevated in kidneys of fetuses that received infusions of ANG-(1-7). Infusion of an ANG-(1-7) antagonist {[D-Ala(7)]ANG-(1-7), 20 mug/h} for 3 days had no effect on fetal blood pressure or renal function. In conclusion, although infusion of ANG-(1-7) did not affect fetal urine flow rate, glomerular filtration rate, or blood pressure, changesin fetal fluids and gene expression indicate that ANG-(1-7) may play a role in the fetal kidney.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:11:05