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Titolo:
Influence of rostral ventrolateral medulla on renal sympathetic baroreflexin conscious rabbits
Autore:
Mayorov, DN; Head, GA;
Indirizzi:
Baker Med Res Inst, Melbourne, Vic 8008, Australia Baker Med Res Inst Melbourne Vic Australia 8008 urne, Vic 8008, Australia
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: R577 - R587
SICI:
0363-6119(200102)280:2<R577:IORVMO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
II RECEPTOR SUBTYPES; C-FOS EXPRESSION; ANGIOTENSIN-II; SUBRETROFACIAL NUCLEUS; SUSTAINED HYPERTENSION; NERVE ACTIVITY; BRAIN; RESPONSES; NEURONS; RATS;
Keywords:
glutamate; rilmenidine; angiotensin II; sarile; arterial pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Mayorov, DN Baker Med Res Inst, POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia Baker Med Res Inst POB 6492,St Kilda Rd Cent Melbourne Vic Australia 8008
Citazione:
D.N. Mayorov e G.A. Head, "Influence of rostral ventrolateral medulla on renal sympathetic baroreflexin conscious rabbits", AM J P-REG, 280(2), 2001, pp. R577-R587

Abstract

Previous studies with anesthetized animals have shown that the pressor region of the rostral ventrolateral medulla (RVLM) is a critical site in vasomotor control. The aim of this study was to develop, in conscious rabbits, atechnique for microinjecting into the RVLM and to determine the influence of this area on renal sympathetic nerve activity (RSNA) and arterial pressure (AP) using local injections of glutamate, rilmenidine, ANG II and sarile. Rabbits were implanted with guide cannulas for bilateral microinjections into the RVLM (n = 7) or into the intermediate ventrolateral medulla (IVLM,n = 6) and an electrode for measuring RSNA. After 7 days of recovery, injections of glutamate (10 and 20 nmol) into the RVLM increased RSNA by 81 and88% and AP by 17 and 25 mmHg, respectively. Infusion of glutamate (2 nmol/min) into the RVLM increased AP by 15 mmHg and the RSNA baroreflex range by38%. By contrast, injection of the imidazoline receptor agonist rilmenidine (4 nmol) into the RVLM decreased AP by 8 mmHg and the RSNA baroreflex range by 37%. Injections of rilmenidine into the IVLM did not alter AP or RSNA. Surprisingly, treatments with ANG II (4 pmol/min) or the ANG II receptor antagonist sarile (500 pmol) into the RVLM did not affect the resting or baroreflex parameters. Infusion of ANG II (4 pmol/min) into the fourth ventricle increased AP and facilitated the RSNA baroreflex. Our results show thatagents administered via a novel microinjecting system for conscious rabbits can selectively modulate neuronal activity in circumscribed regions of the ventrolateral medulla. We conclude that the RVLM plays a key role in circulatory control in conscious rabbits. However, we find no evidence for the role of ANG II receptors in the RVLM in the moment-to-moment regulation of AP and RSNA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:26:52