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Titolo:
Hypoalgesia and hyperalgesia with inherited hypertension in the rat
Autore:
Taylor, BK; Roderick, RE; St Lezin, E; Basbaum, AI;
Indirizzi:
Univ Missouri, Sch Pharm, Div Pharmacol, Kansas City, MO 64108 USA Univ Missouri Kansas City MO USA 64108 armacol, Kansas City, MO 64108 USA Univ Calif San Francisco, WM Keck Fdn Ctr Integrat Neurosci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Anat & Physiol, San Francisco, CA 94143 USAUniv Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Lab Med, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: R345 - R354
SICI:
0363-6119(200102)280:2<R345:HAHWIH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEHAVIORAL NOCICEPTIVE RESPONSES; ALTERED PAIN PERCEPTION; SUBCUTANEOUS FORMALIN; BLOOD-PRESSURE; PRIMARY AFFERENTS; GENETIC-FACTORS; NERVE SECTION; SENSITIVITY; MORPHINE; ANTINOCICEPTION;
Keywords:
pain; inflammation; Dahl salt-sensitive rat; spontaneously hypertensive rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Taylor, BK Univ Missouri, Sch Pharm, Div Pharmacol, 2411 Holmes St,M3-C15,Kansas City, MO 64108 USA Univ Missouri 2411 Holmes St,M3-C15 Kansas City MO USA 64108 SA
Citazione:
B.K. Taylor et al., "Hypoalgesia and hyperalgesia with inherited hypertension in the rat", AM J P-REG, 280(2), 2001, pp. R345-R354

Abstract

Many studies indicate that blood pressure control systems can attenuate pain (hypoalgesia) of short duration; however, we recently found exaggerated nociceptive responses (hyperalgesia) of persistent duration in the spontaneously hypertensive rat (SHR). Here, we used SHR, Dahl Salt-Sensitive (SS), and normotensive control rats to evaluate the contribution of sustained elevations in arterial pressure to nociceptive responses. Compared with Sprague-Dawley and/or Wistar-Kyoto controls, SHR were 1) hypoalgesic in the hot plate test and 2) hyperalgesic in longer latency tail and paw-withdrawal tests and in two models of inflammatory nociception. These differences were not observed between SS and salt-resistant controls fed a high-salt diet. Inflammatory hyperalgesia in SHR was correlated with neither paw edema nor thenumber of Fos-positive spinal cord neurons. Our results indicate that "pain" phenotype of the SHR is not restricted to hypoalgesia. This phenotype isrelated to genetic factors or to the autonomic systems that control blood pressure and not to sustained elevations in blood pressure, differences in spinal neuron activity, or inflammatory edema.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/08/20 alle ore 23:17:09