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Titolo:
Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin
Autore:
Covasa, M; Marcuson, JK; Ritter, RC;
Indirizzi:
Washington State Univ, Dept VCAPP, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 t VCAPP, Pullman, WA 99164 USA Washington State Univ, Program Neurosci, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 eurosci, Pullman, WA 99164 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: R331 - R337
SICI:
0363-6119(200102)280:2<R331:DSIRET>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-FAT DIETS; PLASMA CHOLECYSTOKININ; BODY-WEIGHT; FOOD-INTAKE; AMYLASE RELEASE; ZUCKER OBESE; CCK; LEPTIN; SATIETY; PROTEIN;
Keywords:
high-fat diet; protein diet; satiety; diet adaptation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Covasa, M Washington State Univ, Dept VCAPP, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 ullman, WA 99164 USA
Citazione:
M. Covasa et al., "Diminished satiation in rats exposed to elevated levels of endogenous or exogenous cholecystokinin", AM J P-REG, 280(2), 2001, pp. R331-R337

Abstract

Rats maintained on a high-fat (HF) diet exhibit reduced sensitivity to thesatiation-producing effect of exogenous CCK. Because more CCK is released in response to HF meals than low-fat (LF) meals, we hypothesized that increased circulating CCK associated with ingestion of HF diets contributes to the development of decreased CCK sensitivity. To test this hypothesis, we implanted osmotic minipumps filled with either NaCl or CCK octapeptide into the peritoneal cavity. Subsequently, we examined the effect of intraperitoneal NaCl or CCK (0.5 mug/kg) injection on 30-min food intake. CCK significantly reduced 30-min food intake less in rats implanted with CCK-releasing minipumps compared with those with NaCl-releasing minipumps. Because dietary protein is a potent releaser of endogenous CCK, we hypothesized that rats adapted to a high-protein (HP) diet might also exhibit reduced sensitivity to exogenous CCK. Therefore, in a second experiment, we examined CCK-inducedreduction of food intake in rats maintained on LF and rats maintained on HF or HP. Ingestion of LF stimulates very little endogenous CCK secretion, whereas both HF and HP markedly increase plasma CCK concentrations. Both doses of CCK reduced food intake significantly less in HF and HP rats comparedwith LF rats. There were no differences in 24-h food intake, body weight, or body fat composition among LF-, HF-, and HP-fed rats. These results are consistent with the hypothesis that sustained elevation of CCK either by infusion of exogenous CCK or by dietary-induced elevation of plasma CCK contributes to the development of reduced sensitivity to exogenous CCK.

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Documento generato il 04/12/20 alle ore 09:34:52