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Titolo:
Role of non-NMDA receptors in vasopressin and oxytocin release from rat hypothalamo-neurohypophysial explants
Autore:
Morsette, DJ; Sidorowicz, H; Sladek, CD;
Indirizzi:
Finch Univ Hlth Sci Chicago Med Sch, Dept Physiol & Biophys, N Chicago, IL60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 o, IL60064 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: R313 - R322
SICI:
0363-6119(200102)280:2<R313:RONRIV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULOSUM LAMINA TERMINALIS; CENTRAL-NERVOUS-SYSTEM; NEURONS IN-VITRO; SUPRAOPTIC NUCLEUS; DIFFERENTIAL EXPRESSION; MAGNOCELLULAR NEURONS; GLUTAMATE RECEPTORS; OSMOTIC STIMULATION; AMPA; ACID;
Keywords:
glutamate; kainate; aminopropionic acid; osmolality; supraoptic nucleus; N-methyl-D-aspartate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Sladek, CD Finch Univ Hlth Sci Chicago Med Sch, Dept Physiol, N Chicago, IL 60064 USA Finch Univ Hlth Sci Chicago Med Sch N Chicago IL USA 60064 USA
Citazione:
D.J. Morsette et al., "Role of non-NMDA receptors in vasopressin and oxytocin release from rat hypothalamo-neurohypophysial explants", AM J P-REG, 280(2), 2001, pp. R313-R322

Abstract

Glutamate is recognized as a prominent excitatory transmitter in the supraoptic nucleus (SON) and is involved in transmission of osmoregulatory information from the osmoreceptors to the vasopressin (VP) and oxytocin (OT) neurons. Explants of the hypothalamo-neurohypophysial system were utilized to characterize the roles of the non-N-methyl-D-aspartate (NMDA) glutamate receptor subtypes (non-NMDA-Rs), kainic acid receptors (KA-Rs), and aminopropionic acid receptors (AMPA-Rs) and to evaluate the interdependence of NMDA-Rs and non-NMDA-Rs in eliciting hormone release. Although both KA and AMPA increased hormone release, a specific agonist of the KA-Rs, SYM-2081, was not effective. This combined with the finding that cyclothiazide, an agent that inhibits the desensitization of AMPA-Rs, increased the VP response to both KA and AMPA indicates that the increase in hormone release induced by the non-NMDA agonists is mediated via AMPA-Rs, rather than KA-Rs. Inhibition of osmotically stimulated VP and OT release by a specific AMPA-R antagonistindicated that AMPA-Rs are essential for mediating osmotically stimulated hormone release. NMDA-stimulated VP but not OT release was prevented by blockade of non-NMDA-Rs, but AMPA-stimulated VP/OT release was not prevented by NMDA-R blockade.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:19:07