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Titolo:
Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries
Autore:
Stirrat, A; Gallagher, M; Douglas, SA; Ohlstein, EH; Berry, C; Kirk, A; Richardson, M; MacLean, MR;
Indirizzi:
Univ Glasgow, Inst Biomed & Life Sci, Div Neurosci & Biomed Syst, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland SmithKline Beecham Pharmaceut, Dept Cardiovasc Pharmacol, King Of Prussia,PA 19406 USA SmithKline Beecham Pharmaceut King Of Prussia PA USA 19406 a,PA 19406 USA Glasgow Western Infirm, Dept Cardiol, Glasgow G11 6NT, Lanark, Scotland Glasgow Western Infirm Glasgow Lanark Scotland G11 6NT , Lanark, Scotland Glasgow Western Infirm, Dept Cardiothorac Surg, Glasgow G11 6NT, Lanark, Scotland Glasgow Western Infirm Glasgow Lanark Scotland G11 6NT , Lanark, Scotland Glasgow Western Infirm, Dept Surg, Glasgow G11 6NT, Lanark, Scotland Glasgow Western Infirm Glasgow Lanark Scotland G11 6NT , Lanark, Scotland
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: H925 - H928
SICI:
0363-6135(200102)280:2<H925:PVRTHU>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; PLASMA ADRENOMEDULLIN; ORPHAN RECEPTOR; RAT; CONTRACTION; GPR14;
Keywords:
vasoconstriction; adrenomedullin; sodium nitroprusside; acetylcholine; vasodilators;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: MacLean, MR Univ Glasgow, Inst Biomed & Life Sci, Div Neurosci & Biomed Syst, W Med Bldg, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow W Med Bldg Glasgow Lanark Scotland G12 8QQ otland
Citazione:
A. Stirrat et al., "Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries", AM J P-HEAR, 280(2), 2001, pp. H925-H928

Abstract

The peptide human urotensin-II (hUT-II) and its receptor have recently been cloned. The vascular function of this peptide in humans, however, has yetto be determined. Vasoconstrictor and vasodilator responses to hUT-II wereinvestigated in human small muscular pulmonary arteries [similar to 170 mum internal diameter (ID)] and human abdominal resistance arteries (similar to 200 mum ID). Vasodilator responses were investigated in endothelin-1 (3 nM) precontracted vessels and, in the small pulmonary vessels, compared with the known vasodilators adrenomedullin, sodium nitroprusside, and acetylcholine. In human small pulmonary arteries, hUT-II did not induce vasoconstriction but was a potent vasodilator [-log M concentration causing 50% of themaximum vasodilator effect (pIC(50)) 10.4 +/- 0.5; percentage of reductionin tone (E-max) 81 +/- 8% (vs. 23 +/- 11% in time controls), n = 5]. The order of potency for vasodilation was human urotensin-II = adrenomedullin (pIC(50) 10.1 +/- 0.4, n = 6) > sodium nitroprusside (pIC(50) 7.4 +/- 0.2, n = 6) = acetylcholine (pIC(50) 6.8 +/- 0.3, n = 6). In human abdominal arteries, hUT-II did not induce vasoconstriction but was a potent vasodilator [pIC(50) 10.3 +/- 0.7; E-max 96 +/- 8% (vs. 43 +/- 16% in time controls), n =4]. This is the first report that hUT-II is a potent vasodilator but not avasoconstrictor of human small pulmonary arteries and systemic resistance arteries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:13:02