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Titolo:
Regional differences in mechanisms of cerebral circulatory response to neuronal activation
Autore:
Gotoh, J; Kuang, TY; Nakao, Y; Cohen, DM; Melzer, P; Itoh, Y; Pak, H; Pettigrew, K; Sokoloff, L;
Indirizzi:
NIMH, Cerebral Metab Lab, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 MH, Cerebral Metab Lab, Bethesda, MD 20892 USA NIMH, Div Serv Intervent & Res, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 v Serv Intervent & Res, Bethesda, MD 20892 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: H821 - H829
SICI:
0363-6135(200102)280:2<H821:RDIMOC>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; SOMATOSENSORY-EVOKED POTENTIALS; INSULIN-INDUCED HYPOGLYCEMIA; BLOOD-FLOW; GLUCOSE-UTILIZATION; RAT; INHIBITION; STIMULATION; DEOXYGLUCOSE; ADENOSINE;
Keywords:
adenosine; nitric oxide; caffeine; 7-nitroindazole; N-G-nitro-L-arginine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sokoloff, L NIMH, Cerebral Metab Lab, Bldg 36,1A-05,36 Convent Dr,MSC 4030, Bethesda, MD 20892 USA NIMH Bldg 36,1A-05,36 Convent Dr,MSC 4030 BethesdaMD USA 20892
Citazione:
J. Gotoh et al., "Regional differences in mechanisms of cerebral circulatory response to neuronal activation", AM J P-HEAR, 280(2), 2001, pp. H821-H829

Abstract

Vibrissal stimulation raises cerebral blood flow (CBF) in the ipsilateral spinal and principal sensory trigeminal nuclei and contralateral ventroposteromedial (VPM) thalamic nucleus and barrel cortex. To investigate possibleroles of adenosine and nitric oxide (NO) in these increases, local CBF wasdetermined during unilateral vibrissal stimulation in unanesthetized rats after adenosine receptor blockade with caffeine or NO synthase inhibition with N-G-nitro-L-arginine methyl ester (L-NAME) or 7-nitroindazole (7-NI). Caffeine lowered baseline CBF in all structures but reduced the percent increase during stimulation only in the two trigeminal nuclei. L-NAME and 7-NI lowered baseline CBF but reduced the percent increase during stimulation only in the higher stations of this sensory pathway, i.e., L-NAME in the VPM nucleus and 7-NI in both the VPM nucleus and barrel cortex. Combinations ofcaffeine with 7-NI or L-NAME did not have additive effects, and none aloneor in combination completely eliminated functional activation of CBF. These results suggest that caffeine-sensitive and NO-dependent mechanisms are involved but with different regional distributions, and neither fully accounts for the functional activation of CBF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:26:07