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Titolo:
Involvement of iNOS in postischemic heart dysfunction of stroke-prone spontaneously hypertensive rats
Autore:
Abe, K; Tokumura, M; Ito, T; Murai, T; Takashima, A; Ibii, N;
Indirizzi:
Shionogi & Co Ltd, Dev Res Labs, Dept Drug Safety Evaluat, Osaka 5610825, Japan Shionogi & Co Ltd Osaka Japan 5610825 fety Evaluat, Osaka 5610825, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: H668 - H673
SICI:
0363-6135(200102)280:2<H668:IOIIPH>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; CARDIAC MYOCYTES; MYOCARDIAL-INFARCTION; ADRENERGIC STIMULATION; REPERFUSION INJURY; MESSENGER-RNA; L-ARGININE; EXPRESSION; FAILURE; CELLS;
Keywords:
cardiac hypertrophy; left anterior descending coronary artery occlusion; 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Abe, K Shionogi & Co Ltd, Dev Res Labs, Dept Drug Safety Evaluat, Osaka 5610825, Japan Shionogi & Co Ltd Osaka Japan 5610825 aluat, Osaka 5610825, Japan
Citazione:
K. Abe et al., "Involvement of iNOS in postischemic heart dysfunction of stroke-prone spontaneously hypertensive rats", AM J P-HEAR, 280(2), 2001, pp. H668-H673

Abstract

We investigated the possible contribution of inducible nitric oxide synthase (iNOS) to postischemic heart dysfunction and injuries in stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP, 13-14 wk of age, had significantly higher systolic blood pressure and greater heart weight than age-matched Wistar-Kyoto rats (WKY). Permanent occlusion of the left anterior descending coronary artery (LAD) caused significant and long-lasting increases in the activity and mRNA expression of myocardial iNOS in SHRSP compared with WKY. However, there was no significant difference in the LAD occlusion-induced expression of interleukin-1 beta mRNA between SHRSP and WKY. Hemodynamic deterioration and myocardial fibrosis were also observed in SHRSP at 4 wk after LAD occlusion. Continuous administration of 2-amino-5,6-dihydro-6-methyl-4H-1,2-thiazin (AMT) completely blocked the LAD occlusion-induced increase in the myocardial iNOS activity of SHRSP. Moreover, postischemic heart dysfunction and injuries were also significantly ameliorated by 2-amino-5,6- dihydro-6-methyl-4H-1,2-thiazin (AMT). These results suggest that the increased activity of myocardial iNOS plays a pivotal role in the development of postischemic cardiac dysfunction and injuries in SHRSP with the hypertensive and hypertrophic heart.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 11:51:34