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Titolo:
Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease
Autore:
Brass, EP; Hiatt, WR; Gardner, AW; Hoppel, CL;
Indirizzi:
Harbor UCLA Med Ctr, Dept Med, Torrance, CA 90509 USA Harbor UCLA Med CtrTorrance CA USA 90509 ept Med, Torrance, CA 90509 USA Univ Colorado, Hlth Sci Ctr, Div Geriatr, Sect Vasc Med, Denver, CO 80203 USA Univ Colorado Denver CO USA 80203 tr, Sect Vasc Med, Denver, CO 80203 USA Univ Colorado, Hlth Sci Ctr, Div Cardiol, Sect Vasc Med, Denver, CO 80203 USA Univ Colorado Denver CO USA 80203 ol, Sect Vasc Med, Denver, CO 80203 USA Colorado Prevent Ctr, Denver, CO 80203 USA Colorado Prevent Ctr Denver COUSA 80203 revent Ctr, Denver, CO 80203 USA Univ Maryland, Div Gerontol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 iv Gerontol, Baltimore, MD 21201 USA Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Baltimore, MD 21201 USA Vet Affairs Med Ctr Baltimore MD USA 21201 Clin, Baltimore, MD 21201 USA Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Cleveland, OH 44106 USA Vet Affairs Med Ctr Cleveland OH USA 44106 Clin, Cleveland, OH 44106 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: H603 - H609
SICI:
0363-6135(200102)280:2<H603:DNDAUC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MITOCHONDRIAL ELECTRON-TRANSPORT; COMPLEX-I DEFICIENCY; SKELETAL-MUSCLE; LACTIC-ACIDOSIS; CARNITINE METABOLISM; PARKINSONS-DISEASE; LIVER-MITOCHONDRIA; RESPIRATORY-CHAIN; EXERCISE; DAMAGE;
Keywords:
mitochondria; exercise;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Brass, EP Harbor UCLA Med Ctr, Dept Med, 1000 W Carson St,Box 400, Torrance, CA 90509 USA Harbor UCLA Med Ctr 1000 W Carson St,Box 400 Torrance CA USA 90509
Citazione:
E.P. Brass et al., "Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease", AM J P-HEAR, 280(2), 2001, pp. H603-H609

Abstract

Peripheral arterial disease (PAD) is associated with muscle metabolic changes that may contribute to the disability in these patients. However, the biochemical defects in PAD have not been identified. The present study was undertaken to test the hypothesis that PAD is associated with specific defects in skeletal muscle electron transport chain activity. Seventeen patientswith PAD and nine age-matched controls underwent gastrocnemius muscle biopsies. There were no differences in the mitochondrial content per gram of skeletal muscle as assessed by citrate synthase activity between the PAD patients and the control subjects. Skeletal muscle NADH dehydrogenase activity was decreased by 27% compared with controls when expressed per unit of citrate synthase activity. Expression of enzyme activities normalized to cytochrome c-oxygen oxidoreductase activity confirmed a 26% decrease in NADH dehydrogenase activity and also demonstrated a 38% decrease in ubiquinol-cytochrome c oxidoreductase activity. Thus PAD is associated with specific changes in muscle mitochondrial electron transport chain activities characterizedby relative decreases in NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase activities, which may contribute to the metabolic abnormalitiesand decreased exercise performance in these patients.

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Documento generato il 03/04/20 alle ore 20:26:24