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Titolo:
Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans
Autore:
Garcia, MJ; Firstenberg, MS; Greenberg, NL; Smedira, N; Rodriguez, L; Prior, D; Thomas, JD;
Indirizzi:
Cleveland Clin Fdn, Dept Cardiol, Cardiovasc Imaging Ctr, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ng Ctr, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Cardiothorac Surg, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 c Surg, Cleveland, OH 44195 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 2, volume: 280, anno: 2001,
pagine: H554 - H561
SICI:
0363-6135(200102)280:2<H554:EOLVOS>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; DIASTOLIC FUNCTION; PRESSURE; ECHOCARDIOGRAPHY; PATTERNS; VOLUME; QUANTIFICATION; DETERMINANTS; PERICARDIUM; AMYLOIDOSIS;
Keywords:
diastole; echocardiography; myocardial stiffness;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Garcia, MJ Cleveland Clin Fdn, Dept Cardiol, Cardiovasc Imaging Ctr, Desk F-15,9500 Euclid Ave, Cleveland, OH 44195 USA Cleveland Clin Fdn Desk F-15,9500 Euclid Ave Cleveland OH USA 44195
Citazione:
M.J. Garcia et al., "Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans", AM J P-HEAR, 280(2), 2001, pp. H554-H561

Abstract

Shortened early transmitral deceleration times (E-DT) have been qualitatively associated with increased filling pressure and reduced survival in patients with cardiac disease and increased left ventricular operating stiffness (K-LV). An equation relating K-LV quantitatively to EDT has previously been described in a canine model but not in humans. During several varying hemodynamic conditions, we studied 18 patients undergoing open-heart surgery. Transesophageal echocardiographic two-dimensional volumes and Doppler flows were combined with high-fidelity left atrial (LA) and left ventricular (LV) pressures to determine KLV. From digitized Doppler recordings, E-DT was measured and compared against changes in LV and LA diastolic volumes and pressures. E-DT (180 +/- 39 ms) was inversely associated with LV end-diastolic pressures (r = 0.56, P = 0.004) and net atrioventricular stiffness (r = 20.55, P = 0.006) but had its strongest association with K-LV (r = -0.81, P<0.001). KLV was predicted assuming a nonrestrictive orifice (K-nonrest) from E-DT as K-nonrest = (0.07/E-DT)(2) with K-LV = 1.01 K-nonrest - 0.02; r = 0.86, P< 0.001, DeltaK (K-nonrest - K-LV) = 0.02 +/- 0.06 mmHg/ml. In adults with cardiac disease, E-DT provides an accurate estimate of LV operating stiffness and supports its application as a practical noninvasive index in the evaluation of diastolic function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:00:41