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Titolo:
Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin
Autore:
Matsuoka, N; Ogawa, Y; Masuzaki, H; Ebihara, K; Aizawa-Abe, M; Satoh, N; Ishikawa, E; Fujisawa, Y; Kosaki, A; Yamada, K; Kuzuya, H; Nakao, K;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Clin Sci, Sakyo Ku, Kyoto 6068507, Japan Kyoto Natl Hosp, Ctr Diabet, Kyoto 6128555, Japan Kyoto Natl Hosp Kyoto Japan 6128555 sp, Ctr Diabet, Kyoto 6128555, Japan Kyoto Natl Hosp, Clin Res Inst, Kyoto 6128555, Japan Kyoto Natl Hosp Kyoto Japan 6128555 Clin Res Inst, Kyoto 6128555, Japan Takeda Chem Ind Ltd, Div Pharmaceut Res, Osaka 5328686, Japan Takeda Chem Ind Ltd Osaka Japan 5328686 maceut Res, Osaka 5328686, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 280, anno: 2001,
pagine: E334 - E339
SICI:
0193-1849(200102)280:2<E334:DTLITS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN SENSITIVITY; TRANSFER PROTEIN; GLUCOSE-METABOLISM; MESSENGER-RNA; LIPASE GENE; BODY-WEIGHT; OBESE GENE; EXPRESSION; MOUSE; HYPERTRIGLYCERIDEMIA;
Keywords:
lipid metabolism; very low density lipoprotein-triglyceride; lipoprotein lipase; transgene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ogawa, Y Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Sakyo Ku, 54 Shogoin Kawahara Cho, Kyoto 6068507, Japan Kyoto Univ 54 Shogoin Kawahara Cho Kyoto Japan 6068507 07, Japan
Citazione:
N. Matsuoka et al., "Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin", AM J P-ENDO, 280(2), 2001, pp. E334-E339

Abstract

Leptin is an adipocyte-derived circulating satiety factor with a variety of biological effects. Evidence has accumulated suggesting that leptin may modulate glucose and lipid metabolism. In the present study, we examined lipid metabolism in transgenic skinny mice with elevated plasma leptin concentrations. The plasma concentrations of triglycerides and free fatty acids intransgenic skinny mice were 71.5 (P < 0.01) and 89.1% (P < 0.05) of those in their nontransgenic littermates, respectively. Separation of plasma intolipoprotein classes by ultracentrifugation revealed that very low density lipoprotein-triglyceride concentrations were markedly reduced in transgenicskinny mice relative to the controls. The clearance of triglycerides estimated by a fat-loading test was enhanced in transgenic skinny mice; the triglyceride concentration in transgenic skinny mice 3 h after fat loading was 39.7% (P < 0.05) of that of their nontransgenic littermates. Postheparin plasma lipoprotein lipase activity increased 1.4- fold (P < 0.05) in transgenic skinny mice. Our data demonstrated a significant reduction in plasma triglyceride concentrations, accompanied by increased lipoprotein lipase activity in transgenic skinny mice overexpressing leptin, suggesting that leptinplays a role in long-term triglyceride metabolism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:18:59