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Titolo:
Increased weight gain after ovariectomy is not a consequence of leptin resistance
Autore:
Chen, YY; Heiman, ML;
Indirizzi:
Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Div Endocrinol, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 inol, Indianapolis, IN 46285 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 2, volume: 280, anno: 2001,
pagine: E315 - E322
SICI:
0193-1849(200102)280:2<E315:IWGAOI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROOPIOMELANOCORTIN MESSENGER-RNA; OBESE GENE-PRODUCT; BODY-WEIGHT; FAT DISTRIBUTION; NEUROPEPTIDE-Y; FEMALE RATS; FOOD-INTAKE; OB/OB MICE; EXPRESSION; ADIPOSITY;
Keywords:
rat; indirect calorimetry; energy expenditure; leptin sensitivity; body composition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Heiman, ML Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Div Endocrinol,DC0545, Indianapolis, IN 46285 USA Eli Lilly & Co DC0545 Indianapolis IN USA 46285 s, IN 46285 USA
Citazione:
Y.Y. Chen e M.L. Heiman, "Increased weight gain after ovariectomy is not a consequence of leptin resistance", AM J P-ENDO, 280(2), 2001, pp. E315-E322

Abstract

The positive correlation between leptin and body fat mass has caused some investigators to speculate that leptin resistance contributes to obesity. Loss of ovarian function in human and rat is associated with increased fat mass gain and increased circulating leptin levels. To study whether ovariectomy produces leptin resistance, Sprague-Dawley female rats were ovariectomized or sham operated and injected with leptin for 35 days. Ovariectomy (OVX) produced hyperphagia and increased gain in both lean and fat mass. Daily leptin injections initially decreased food intake significantly, but feeding gradually increased to a stable level by day 16 and remained at that level for the duration of study. Body composition analysis indicated that chronic injection of leptin to OVX rats dramatically decreased (P < 0.05) fat mass [30 +/- 2 (SE) g, vehicle, to 3 +/- 1 g, leptin]. Using indirect calorimetry, we observed that OVX did not change energy expenditure or total levelof fuel utilization. Leptin administration increased fat utilization and prevented reduction in calorie expenditure that is typically associated withfood restriction. Leptin treatment to OVX rats decreased plasma triglyceride, free fatty acid, and insulin concentrations, whereas glucose concentration was normal. Withdrawal of leptin triggered hyperphagia, indicating thatleptin biology remained throughout the duration of the chronic treatment. The same dose of leptin produced qualitatively similar data in sham-operated rats. Thus we concluded that the loss of ovarian function in rats is not associated with a change in leptin sensitivity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:30:00