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Titolo:
Serum cystatin C concentration as a marker of renal dysfunction in the elderly
Autore:
Fliser, D; Ritz, E;
Indirizzi:
Hannover Med Sch, Dept Internal Med, Div Nephrol, D-30625 Hannover, Germany Hannover Med Sch Hannover Germany D-30625 rol, D-30625 Hannover, Germany
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 1, volume: 37, anno: 2001,
pagine: 79 - 83
SICI:
0272-6386(200101)37:1<79:SCCCAA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; CREATININE CLEARANCE; AGE; HYPERTENSION; DECLINE;
Keywords:
cystatin C; creatinine; elderly; glomerular filtration rate (GFR); renal function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Fliser, D Hannover Med Sch, Dept Internal Med, Div Nephrol, Carl Neuberg Str 1, D-30625 Hannover, Germany Hannover Med Sch Carl Neuberg Str 1 Hannover Germany D-30625 ny
Citazione:
D. Fliser e E. Ritz, "Serum cystatin C concentration as a marker of renal dysfunction in the elderly", AM J KIDNEY, 37(1), 2001, pp. 79-83

Abstract

Serum cystatin C is a novel marker of renal function claimed to be superior to plasma creatinine, We assessed both parameters in young normotensive subjects (n = 12; 6 men; mean age, 25 +/- 2 years) and elderly normotensive and hypertensive subjects (n = 41; 19 men; mean age, 67 +/- 6 years). Glomerular filtration rate (GFR) was measured in all individuals using the inulin clearance (C-in) technique. Compared with young subjects, mean GFR was modestly but significantly (P < 0.001) less in elderly subjects (young, 119 +/- 11 mL/min/1.73 m(2) versus elderly, 104 +/- 12 ml/min/1.73 m(2)). Mean plasma creatinine concentration was identical in both groups (young, 0.93 +/- 0.11 mg/dL versus elderly, 0.93 +/- 0.10 mg/dL; P < 0.90). Mean serum cystatin C concentration was significantly (P < 0.001) greater in elderly subjects (0.84 +/- 0.10 mg/L) compared with young subjects (0.69 +/- 0.08 mg/L). In all butone elderly subject, plasma creatinine concentration was withinthe 95% confidence interval of plasma creatinine concentration in young subjects. Eleven of 41 elderly subjects (27%) had GFRs less than the lower 95% confidence interval, respectively, ant! 12 of 41 elderly subjects (29%) had a serum cystatin C concentration greater than the upper 95% confidence interval in young subjects. The correlation between serum cystatin C concentration and C-in (r = -0.65; P < 0.001) was considerably better;than betweenplasma creatinine concentration and C-in (r = -0.30; P < 0.02). Serum cystatin C concentration is a better marker of renal dysfunction (ie, reduced GFR) than plasma creatinine concentration, at least in elderly subjects withplasma creatinine concentrations within the normal range. (C) 2001 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:46:20